ID A0A101U7A0_9ACTN Unreviewed; 569 AA.
AC A0A101U7A0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=AQJ58_39740 {ECO:0000313|EMBL:KUO05501.1};
OS Streptomyces sp. DSM 15324.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1739111 {ECO:0000313|EMBL:KUO05501.1, ECO:0000313|Proteomes:UP000053431};
RN [1] {ECO:0000313|EMBL:KUO05501.1, ECO:0000313|Proteomes:UP000053431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15324 {ECO:0000313|EMBL:KUO05501.1,
RC ECO:0000313|Proteomes:UP000053431};
RA Ruckert C., Winkler A., Kalinowski J., Wink J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. DSM 15324, isolated from soil.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO05501.1}.
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DR EMBL; LMXA01000063; KUO05501.1; -; Genomic_DNA.
DR RefSeq; WP_067259483.1; NZ_KQ949049.1.
DR AlphaFoldDB; A0A101U7A0; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000053431; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KUO05501.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053431};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KUO05501.1}.
FT DOMAIN 17..243
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 302..532
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 546..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 59356 MW; E7BAF8CFF1263BB3 CRC64;
MSPTALPAAA VPEHGHVTFL GAGPGDPGLL TLRAVEALAN ADVLVAEHEV LDVVRTHARP
GVSVVNAETG PSSDPLPGTG TPVPTLVDGT STSVEVPAVR DASHLVMEAA RGGRRVVRAV
SGDPGLDTYA AEEMLACAAA GVPFEVVPGV AAAVGVPAYA GVPLRDAQGA DVRFVDARTA
SDRCWTEVGA SDGTVVVSTT LDSVAAAAGE LVAAGRKPDT PMTVTVAGTT TRQRTWSATL
GTIAQTLKQA KVLPSPDGGR PVIAVVGERS APAQRAQLAW FESKPLFGWK VLVPRTKEQA
ASLSDQLRSY GAVPHEVPTI AVEPPRTPQQ MERAVKGLVT GRYEWIAFTS VNAVKAVREK
FEEYGLDARA FAGIKVAAVG EQTAKALIAF GVKPDLVPSG EQSAAGLLED WPPYDPVFDP
IDRVFLPRAD IATETLVAGL IELGWEVDDV TAYRTVRASP PPAETREAIK GGGFDAVLFT
SSSTVRNLVG IAGKPHNVTV IACIGPATAK TAEEHGLRVD VMAPEPSVHK LAEALADFGL
RRRAAALDAG DPVTRPSERR PGSRRRRAT
//
