ID A0A101U7V6_9ACTN Unreviewed; 4607 AA.
AC A0A101U7V6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KUO05624.1};
GN ORFNames=AQJ67_05650 {ECO:0000313|EMBL:KUO05624.1};
OS Streptomyces caeruleatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=661399 {ECO:0000313|EMBL:KUO05624.1, ECO:0000313|Proteomes:UP000053429};
RN [1] {ECO:0000313|EMBL:KUO05624.1, ECO:0000313|Proteomes:UP000053429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUO05624.1,
RC ECO:0000313|Proteomes:UP000053429};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT strain for the species Streptomyces caeruleatus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO05624.1}.
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DR EMBL; LMWY01000004; KUO05624.1; -; Genomic_DNA.
DR RefSeq; WP_062716934.1; NZ_KQ948925.1.
DR STRING; 661399.AQJ67_05650; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000053429; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010037; FkbH_domain.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010033; HAD_SF_ppase_IIIC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01686; FkbH; 1.
DR NCBIfam; TIGR01681; HAD-SF-IIIC; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053429};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..93
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 112..536
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1748..1823
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1851..2275
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3525..3601
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 3600..3620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4607 AA; 488066 MW; 35E351B12136F3EA CRC64;
MPAPDSPKQF SEPSLTTPDG VRAWLESAVA EAAGLDPLAV DPERPIAELG LGSRQLVTLA
ADLSAATGRT LDPSLIFNHP TVAALAQAVF DETPTRTRAA AAPTDRAPAR ADDDIAIISM
ACRFPGGADN PEALWRLLAA GEDAITEVPS GRWDTRGLHD PDPDATGKAY SLRGGYLSGI
DRFDAAFFGI SPREAAAMDP QQRLLLETAW EAIERAGIVP DTLNGSSTGV YVGLYDSGYL
ASAALDQLDG HVGTGSASSV ASGRIAYTLG LQGPAVTVDT ACSSSLVALH LAARALAGGE
CDLALAGGAT LLVTPRGHVE FSRLRGLSPS GRCSPFSADA DGVVWAEGCG VVLLKRLADA
RRDGDRILAV VKGSAINQDG RSQGLSAPNG PAQERVLRAA LDEAGLQPHD LDHIEAHGTG
TPLGDPIEGG ALAAVFGPDR PAERPLGVGS LKSNIGHTQA AAGIASVIKT VLALDHARIP
ASLHAGAPTG HIDWAHSGLR LIDEPQSWPR HPERVRRAGV SAFGISGTNA HVVLEEAPEE
QPVEPAADLP GPALFPLSAR TLSALRAQAA RLRESLERQP APPLPAVAAT LAHHRTHFEH
RAVVRASDRA ELLTALRELA EDRPDTELIT GPELALTTGK LAFVCPGQGS QWSGMARDLL
DRDPVFADEL DRCDAALRPF TGWSVTSVVR GDTGAPNLER VDVVQPVLFA VMVSLAAVWR
ARGIRPDAVV GNSQGEVAAA CVAGALSLND AAAVVALRSQ ALTGLSGTGT MAVVALPHTD
VEAKLADHGG QIGVAAVNSG RSTVVAGAVD AVEAFLADLD RQQVFVRRLD VDYASHSAQV
EPLRTTILDE LDGVTTCPTP VTWYSTVTGE PVTEELEADY WYTNLREPVR FAPTVERMAA
DGYRYFVELS PHPALLTALR TVDEDLIAVG SLRRDEDGPA CVDRATAELH VHGRHIDWRR
PVPHTTPADL PTYAWDARRH WTEPAASATA PGLFDRAAHP LLGIQLQSAD RTRWTFRDEW
SPATAGWLPD HTVFGHTVVS GTTLLELCRA ALATARPDTP ADIGDLLLLA PLTLPATGTV
EVSVEVVTAG AAPEITIHSR PRGQEATDWT LHATASAAEP ASLPAGEPPA WPETAEPAWH
EDTYERLTGL GLRYGPAFQG VRQAAVTGDG TVLARLTLPA VARDTTDPYP VHPALLDAAL
HVAAALDSSE ERVLLPVAMA RCVLPPGTAT DLIASVRRAD GSGTDATLDV TLWDTDGFPA
GRLEGVRLRG ANPADLHSAS ENGRHLYEVA WTAVPKTPTG APGTAWAVHG DGSDPAVATA
LRDLRAAGIR ITDEGADTVL RVWPRTAPDA EPAVAAQELA ATALTELQTL IALPPDRAPA
RTIWVTRGAV AAADGDTVAG LAQSVLWGLA RSARAEHPGL GLTLLDLDLD GDETPLLTAA
AHADEPEIAL RDGDLLVPRL VRARPAPSGR SAPIPVDGTV LITGGLGAVG RSIARWLAEN
GVPRLLLTSR QGAGDPRAAD VVAELAGLGA EVEIAACDVA DGSAVAGLLA GIGDEAPLRG
IVHCAGVLAD GVVAELTAER LAQVLRPKVD GAAHLHRLTA GRPLDLFLLV SSAAGVVGNA
GQANYAAANA FLDQLAHHRR ALGLPGVSVA FGAWAGEGLA AQHADLERMA RLGHRALTPD
QGRELTELAL RRDTAHLVAW ALDLPRLRAA APEGALWRSL LPARRPDRAG GRTLADRLAR
LPEPERPARV LALVREEAAH ALGLRSAESV RPDQPLRDLG MDSVTAVDLR NRISTRLGTR
LPATLLFDHP TPTRLAEYLL TGVLATTGSA GRELTSTSTS ASPSTPALAS DEPVALVAMA
CRLPGGVSDP EGLWRLVAEG RDAVGPFPAG RWDVESLYDP DPDALGKSYA REGGFLDDIE
SFDAGFFGIT PKEAAAMDPQ QRLLLETAWE SLERAGIVPA DLAGSTTGVY VGMFGSDYLS
GTRLDQLDGY VGTGSALSVA SGRLAYTLGL NGPALTVDTA CSSSLVAVHL AAQALRAGEC
DLALAGGVTL MVTPQTFVEF SRLRGLSPTG RCRSFSDSAD GAIWAEGAGM VVLKRLTDAR
RDGDRVLAVL RGTAVNQDGR SQGLSAPNGP AQEQVIRQAL ERSGLTPADI DHVEAHGTGT
TLGDPIEANA LAEVFGATRP EGRPLHLGSL KSNIGHAQAA SGVLGLIKVV QSLTHETLPR
TLHADTPSRH VDWSDSGLHL LREETAWPAS EQRIRRAGVS AFGISGTNAH VIVEEAGPAT
AEPPAEVLPG KRLFVLSGRS ETGLRGQAAA LAHHLAAVDS AADADTALSD TAHTLAHHRS
HFERRTAILA DGRDELRSVL GELASGRIPL PSPREEHTGK VAFVHAGHGG QWPGMGLELM
AESDAFREEL TRIDEAVERQ AGWSVLNALR APEEFSPLER TEYLQPTLFA VNAALAAAWR
SLGVTPDAVT GHSLGEIAAA YSAGALTLDD AVTVVTGRAR AVVPVAGKGG MLSLDLPRPR
VEELLAPYAG RLFVAAVNSP HSTAVSGTGD ALAELRRSPD EQGIEARSLS TPFASHTPLM
APLRQDLLDR LRGIRGARTA VPLYSTVLAE PVPGDRLDPA YWYANLSEPV RFADTIRRML
DDGYRYFVEL SPHPSLGSTI EAVAAEAGID AVSVGSLRRQ RGGRDVLLCR LGELYTAGHT
PDWSALFPAG HRVDLPTYAF ARERHWLAPA PAPATATGAS PLLGTHVEAS DDADRHLFQT
EVDLRDNRFA YLTDHRVTGE VWLPGAAFLG MALEAAATVR DGDDVRLHDV GFLQPLRLDE
SGPTRLQLVL KPAVDGFRDF TISSAPATDG PRARWERHVD GRIAVTPTEP TEPTEPTADP
TAPPAVLRAQ CTQPADLPTV YGTLAALGIE YGPAFRGLES GRRSHAAAVA RLADRPAAGH
LLHPAVLDAA FHTAALPEDA PQGRAFVPAG VARLRHTGLR TTPAWVTCEL RSVSGDTATL
DLRLYDDEDQ LLLEAEEFRL AALSPLDGAL FETRWQPRPP ADQPPAPGSW LVLADESGVA
ADLVERLGTS VPCVIARRGE EFAAEGPGRY VLDTADPGQL ARLLDEAFAH EPPQRVVQLS
ALDAPAIEDG RTAEEAARLC CLSTLHLVRA LADRAQAPRL FVVARGSQAA GDSAQVTHPQ
QALAWGFGLA LAQEHPELRT TLVDLPPTDG ADALWTQLWH ADDERLVALR DDARLVPRLV
RTRPDDSGQG ATSPDGAYLI TGGLGGLGRV VAERLVRRGA RRLALMSRGA PNADALGWIR
GLEERGATVH VARADVADRE GLAAALETVR QELGPITGVV HAAGVLDDAT IANQTDERVL
RVLGPKVLGT ALLTELTPDA DDFVLFASAA GLLGSAGQSP YSAANAFLDA WAHHLSLRDR
RALSLDWGAW AGVGMVSESG VREAQTARSG LLALSAQDGG ELFERVLTTS RRQLAPMALD
WDLLALDPDA ARTRPTLADL ITAPTGTPAA DDLVKHVFAA TTDTERAVRL EAYVRARVGE
VSGGAVQVSA TTALKELGLD SLMLVRLRNA FARELGVELP AATVFSAADI RGLAQALSTA
LPERDTPAPH EPRRPAEVPS TELHPVTRDV VRLLRSAGPG MPDAAHAVGL AVRLTTPTTR
EALTGILGRL TARHAALRTA VVTADEGGRQ LRVDREPPET LLRWTVVPQD TALDAAEWLR
GLLEPPFDLT VAPLWRFELL DGAERGQILV YGAHHAVSDL QSLLLVAAEI DAELSGDALD
DTVTNRDVRL LIEAQQTGGR TGGQVEGQVD GSARADEWRE AFQGSARLDL ALSRPRPQTR
SYRAGSVTVP IPDGLMDRIS TAASRLAVTP AAFCLGTLTV LLARKRERER FVLAVPVDTR
IHADAYDAVG FFGVPVPFPA EANAGERIEE VLRRTDGRLQ RVLTKGAMFS DVLPALARQG
LYRANAPLVE VYFNYIRAAR GLSALEVLPA GTGYSDLDLM ITMTPDAGRI RLDHNLDILD
AAAVAELGEE LLRLLAETAD DPRGPARIPA PVAEQAAARV AEQAAAPVAA PAPAPAGARP
DRLALAATFA LGNLPLMCET ALAAAAPDSP ATVAEAPYHH VLAGLRDPSG VFADPATTTG
VVLLRATDLQ RFGPVDDTLL AELRTAYPAA LRAVAERTRK PLIVGFPPTA QAEDRLRRWE
QQIAAELAEE PGIAVLGPDD WTRHHPVEER FDGRTEHLAH LPFTAPFQAA VALRLAEAVR
AVRRPAPKVI AVDGDETLWG GVAGEIGSEA VDLTGPRALL ARRLLRWRAA GALLVLVSNN
DEDVVRAVLN RPDSPLKAEH FSVISAAWNP KPARLAEAAG TLGLGLDSFL FLDDNPAEIA
KMRAALPQVL SVTCPSAAEL PEFLGRLWPL VPAAATAEDA LRARFYEQER ERDAVRAEAG
FEAFLAQLEL EVDVRALSEP DVQRAEQLVR RTNQFTLHAR SADGGDVARW REHGEVWTAT
ARDRFGDYGQ IGLLAVRREG DRLDVLAWLM SCRALGRGVE ERLLGWLADR AEELDCAKVR
LTAERTARNT PARRLLSALG GGDQDDDRLE TVVTPEHLRT FRSWRRP
//
