ID A0A101U9D3_9ACTN Unreviewed; 1004 AA.
AC A0A101U9D3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:KUO06627.1};
GN ORFNames=AQJ67_01325 {ECO:0000313|EMBL:KUO06627.1};
OS Streptomyces caeruleatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=661399 {ECO:0000313|EMBL:KUO06627.1, ECO:0000313|Proteomes:UP000053429};
RN [1] {ECO:0000313|EMBL:KUO06627.1, ECO:0000313|Proteomes:UP000053429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUO06627.1,
RC ECO:0000313|Proteomes:UP000053429};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT strain for the species Streptomyces caeruleatus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO06627.1}.
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DR EMBL; LMWY01000001; KUO06627.1; -; Genomic_DNA.
DR RefSeq; WP_062716081.1; NZ_KQ948924.1.
DR AlphaFoldDB; A0A101U9D3; -.
DR STRING; 661399.AQJ67_01325; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000053429; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053429}.
FT DOMAIN 519..597
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 634..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 111188 MW; 77EA75B593026C58 CRC64;
MHDDRSLVEA RLKRVLDERV RPAVYPESVP LDVAVWHAPG EPVPVAEGLA AEPEAIEVGA
RWGAPWGTSW FRVTGTVPEA WAGKTVEALL DLGFDENMPG FQCEGLVYRP DGTPVKGLNP
RNQWVRIGAP VEGGEEVCLH IEAASNPVIL DYHPFLPTQL GDKETAGSEP QYTLTRMDLA
VFDETVWQLV LDLEVLGELM AELPVESARR WEILRAVEKA LDAIDLQDVG GTAARARSRL
TRVLATPAVP SAHRISAVGH AHIDSAWLWP LRETVRKVAR TTSNMTALIE DEPDFVFAMS
QAQQWAWVKE HRPEVWARVK KAVADGRFVP AGGMWVESDT NMPGSEAMAR QFVHGKRFFL
DEFGIENDEA WLPDTFGFAA GLPQIIKAAG SKWLLTQKIS WSQTNKFPHH TFQWEGIDGT
RIFTHFPPVD TYNCSMKGSE IAHAARNFKD KGRARHSLAP TGWGDGGGGT TREMVAKAAR
LRDLEGSATV VWETPDAFFR KAEAEYPEPP VWVGELYLEL HRATLTSQAR TKQGNRRSEH
LLREAELWAA TAAVRAGFPY PYDELDRIWK TVLLHQFHDI LPGSSIAWVH REARKTYEQV
AEELTGIIRA AQRALAGDGE RILLFNSAPH TRAGVPAGGV GTPETQGRTR VTPRPDGGHV
LDNGLLRVEV DGRGLVVSVY DIDADRETIA PGGAANLLQL HSDFPNMWDA WDVDEFYRNT
VTDLTDARIV DESGDGVRVV RAFGSSRVTQ RLSLAPGDKR LLVDTVVDWH ETEKFLKLAF
PLDVHAERYA SETQFGHFHR PTHTNTSWEA AKFEACNHRF VHLAEPGWGV AVVNDSTYGH
DVTRTVRTDG DRGTTTTVRV SLLRAPRFPD PETDQGVHRF RHALVPGAGI GDAVREGWRI
NLPERRVSGG VDEVAPLVTV DQDAVVVTAV KLADDGSGDV VVRLHEAHGG RVRATLTAGF
EVADVVATDL LERALPEAPA YDGRRVALRL RPFELVTLRL RRAL
//
