ID A0A101UA17_9ACTN Unreviewed; 1755 AA.
AC A0A101UA17;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KUO06721.1};
GN ORFNames=AQJ58_39260 {ECO:0000313|EMBL:KUO06721.1};
OS Streptomyces sp. DSM 15324.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1739111 {ECO:0000313|EMBL:KUO06721.1, ECO:0000313|Proteomes:UP000053431};
RN [1] {ECO:0000313|EMBL:KUO06721.1, ECO:0000313|Proteomes:UP000053431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15324 {ECO:0000313|EMBL:KUO06721.1,
RC ECO:0000313|Proteomes:UP000053431};
RA Ruckert C., Winkler A., Kalinowski J., Wink J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. DSM 15324, isolated from soil.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO06721.1}.
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DR EMBL; LMXA01000050; KUO06721.1; -; Genomic_DNA.
DR Proteomes; UP000053431; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053431};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1569..1644
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 593..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 182182 MW; E1C454817D9BE741 CRC64;
MSSFGLSGTN AHVVLEEPPV EPVADPVPVP VVDGVVPWVV SGRTAAALRA QAGRLAEFVA
GDETLGAAEI GGALVRSRSL FEHRAVVWGS DRTELLRALE AVASGDEAPN AATGMARREA
RTAFLFAGQG SQRLAMGREL YDTYPAFADA FDAACAHFDT EVPRPLREVV FGEDADLLNR
TEFTQPALFA LEVALFRLLE SWGVRPDVLA GHSIGEIAAA HVAGMWSLAD ACRLVAARGR
LMQALPAGGA MVALQAAEDE VLPLLGDEVG VAAVNGPRAV VIAGAADAVA EIADRFRALD
RKVTALRVSH AFHSPLMEPM LADFRKVAES LTYERPKLPM VSTVTGEVAS ADEVMSADYW
VAHVRRPVRF ADAVRVLAGQ GVGRWVELGA DGTLTALAQA CLDDTGAVVM TPVLRKDRPE
AAALLAAVAT LFVNGADADW STLTGGDRGP TPNLPTYAFQ RRRHWPDFTG VTLGDLGSAG
LGSAEHPLLG AAVRVAGSEE ALFTGRLSLR SHPWLRDHAV TGTVLFPGTG FLELALCAAG
QLGYDRVEEL TIAAPLVVPE RTGRLVQVRV GEPDESDTRT VEVYSRAEDA LDTDPWTLNA
SGSLSADPEP DTAAPDLTAW PPPNAEAVPM EGFYDRFAEA GFAYGPVFQG LRAVWRRGEE
VFAEVGLPDE HDRLAGDFGL HPALLDSALH AMMFVSLADA GQGRLPFSWS GVSLRASGAR
SLRVRMVQAG PEAVALQLAD PTGGTVAAVE SLLLRQVSGD LAARAEADGH RDGLFQVDWT
KVSPTERDAA SAGALAAVGA VGPVPGAVSY PTLAELPATV PATVLFAAGG GLGADGDAAA
AARVATGRVL DAVRSWLADE RFEESRLVVV TEGAVTLDGT APDPALAAVW GLVRAARAEA
PDRFALVDTD GTEASRAVLA QALGTGEPEL ALRDGVPHAP RLGRVPTGDG LPLPAGAPAW
HLDSVEKGTL DNLALTPFPE AAAELTEGQV RIAVRAAGVN FRDVLNALGM YPGEAGLLGG
EGAGVVTEVG PGVSHLAVGD RVFGMFPGSF GPVAVADART VARVPRGWSF AEAASVPIVF
LTAYYALTDL GAVKPGESVL VHAAAGGVGM AAVQLARHLG AEVFGTASAG KWDTLRALGL
DEGHIASSRD LTFESAFLAA TGGDGVDVVL DSLAGEFVDA SLRLLPRGGR FLEMGKTDVR
DPETVAAEHA GVQYRAFDLW EAGPERIGRM LADLVALFEA EVLQPLPVTC WDVRRAPDAF
RYLSQARHVG KVVLTVPVPL DRDRTVLVTG GTGGLGALVA RHLVTEHGVR RLLLASRRGP
DAPGAAELLA ELAASGAEVE AVAVDVADRD QLAAALDGHV LTAVVHTAGI VDDGVVASLT
PERLAEVMRP KADAVAHLHE LTRDADLSAF VVFSSVAGTF GSAGQANYAA ANAFLDAFAA
RRRSAGLPAV SLAWGAWAPG AGMTADLTEA DLRRMARGGM RPLTAEQGLA LLDTAGLVAP
TAPAHRALLL PVNLDLQALR AHAEAVPPLL RGLVRAPARR AAQTAAGAGA ERQDLGALLA
ALAPADREQH LVDLVCAQAA ATLGHASADE IEPDQAFKEL GFDSLTAVEL RNRLNAATRL
RLPATLVFDH PTPTALAAHL LEGITLPEAS GTGAGEGPGA AVQAAPLLVE LDRLEAALAA
AAVGGDDHAT ITSRLQRLTA KWQEKTTKGG GAGHDNGTGS GGSGAALADV DDGELDSVET
ADELFDLIDK ELGMS
//