ID A0A101UQG1_9ACTN Unreviewed; 1156 AA.
AC A0A101UQG1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=AQJ91_44050 {ECO:0000313|EMBL:KUO14943.1};
OS Streptomyces dysideae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=909626 {ECO:0000313|EMBL:KUO14943.1, ECO:0000313|Proteomes:UP000053260};
RN [1] {ECO:0000313|EMBL:KUO14943.1, ECO:0000313|Proteomes:UP000053260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RV15 {ECO:0000313|EMBL:KUO14943.1,
RC ECO:0000313|Proteomes:UP000053260};
RA Ruckert C., Abdelmohsen U.R., Winkler A., Hentschel U., Kalinowski J.,
RA Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. RV15, isolated from a marine
RT sponge.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO14943.1}.
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DR EMBL; LMXB01000127; KUO14943.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101UQG1; -.
DR STRING; 909626.AQJ91_44050; -.
DR OrthoDB; 9776021at2; -.
DR Proteomes; UP000053260; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KUO14943.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053260};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 318..502
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 696..1045
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
FT REGION 1088..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 130860 MW; CEACCCD853FB52D7 CRC64;
MPEEWIRALV ADFGSECRER LRVSDTEASI SLPVAKLVET FGARWRLSPR LHPEYPLPEA
RVRPDYAVET SGRITGFLEL KAPGHDVTPD GFTKRDREQW ELMRRLPNVL YSNGHTWCLY
RGGLRPLRTV RLEGDLYRSG SRLRTSEADG AAFRDLLREF LGWQPQRITT VGQLVSSIAP
LCQYLREEVL EQLALERRTP DGPRSRRRAP KPFTALAHHW SKVLFPSTDG QDPDHLFADR
YTQTIAFALL LARIENVPLA GRNFVDVARE LKAENTVMGR ALQLLTETVD AEFARRIDTL
VQVIDAVDWE AIRARTPDAH VHLYEDFLQE YDRELRKRSG TYYTPPRLVK EMVRFTDAVL
RTRLGCVEGF ADEQVTIVDP AMGTGTFLSE IIDRVAEERS RRGEGFRGEA VEQLAGRLIG
FERQMAAYAV AQMRITQTLR KQVTDTQLGD LRLHLADTLA DPYERATLFT FLPDGDPLVE
NTRKADWIKR EQKVTVMISN PPDRERAEGE GGWVEKGREG DDKAPLLDAF RLGGRNGVHE
NKLKNLYVYF WRWATFKVFE QHRSESDRGI VAFISTAGFL SGPGFRGMRK YLRETCSEGW
IIDLSPEGIQ PPLRTRLFEG VQQQLTIAVF VRSRADTEPA HIRYVALDGS TREEKYAQLE
ALGPDSDQWR PVRQDAHAPF TPAALGAWDT YPALDDLLPW TVPGILPKRT WVYSSDPDTL
RSRWRRLTAE TDIAEKRALF RETKGGRTVD RPVKPLPGSA QRRRSMLEAG PECPEPVPVA
FRPFDRQWII PDNRVLDRCS PELWENRAEG QIHMVELHSE RFGDGPATLF TALMPDMHHF
AGWGGGRVIP FLQKDGTPNA TPGLLQHLRN SFGGLAVSAE DLIAYIAAIT AHPGFRSRFD
DELTTIGVRV PLTGDAALWS EALHIGRKVI WASTFGERLV DPVAGRPGGP QEVWATAQPA
ITYRRQVGRD ELPESFVYDP DRLELHFGQG VFVSVTQQMR DYQVSGQNVL DGWLKRRTGP
PSRRAVSQLD HIRPDRWQPA WSEELQHVLA VLWHLVELQS AQNELLDRVL TSPLVSVAEL
QRRNVLPVPE TARRSAPAPI QTDPIPGTEG IEAREPHAVR PLTAEKSSSA TAPMARSRRS
RNSGAAQSPR RKRQDP
//
