ID A0A101UUX3_9ACTN Unreviewed; 563 AA.
AC A0A101UUX3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:KUO17290.1};
GN ORFNames=AQJ91_30975 {ECO:0000313|EMBL:KUO17290.1};
OS Streptomyces dysideae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=909626 {ECO:0000313|EMBL:KUO17290.1, ECO:0000313|Proteomes:UP000053260};
RN [1] {ECO:0000313|EMBL:KUO17290.1, ECO:0000313|Proteomes:UP000053260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RV15 {ECO:0000313|EMBL:KUO17290.1,
RC ECO:0000313|Proteomes:UP000053260};
RA Ruckert C., Abdelmohsen U.R., Winkler A., Hentschel U., Kalinowski J.,
RA Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. RV15, isolated from a marine
RT sponge.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO17290.1}.
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DR EMBL; LMXB01000076; KUO17290.1; -; Genomic_DNA.
DR RefSeq; WP_067028110.1; NZ_KQ949098.1.
DR AlphaFoldDB; A0A101UUX3; -.
DR STRING; 909626.AQJ91_30975; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000053260; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:KUO17290.1};
KW Hydrolase {ECO:0000313|EMBL:KUO17290.1};
KW Nuclease {ECO:0000313|EMBL:KUO17290.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053260}.
FT DOMAIN 311..522
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 101..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 61016 MW; BE396A9ECEED02AE CRC64;
MTDRWALAPA EDGGVEIAPL GRDGLPAGPV YREADLAGAV RGRPEVARWV WRSTAEVYPR
LLATGVRVER CYDIEDAETL LLGHEGRHGE PRSAAAALAR LRGGPVPPDP PQRSAEPGAQ
SSLFEPQSVP LPLADLVEVY ADQQRRHDAT AHPERMRLLT AAESAGMLVA AEMNRSGLPW
SAEVHRQVLH DLLGERYAGG GEPRRLAELA DEVSAAFGRR VRPDLPADVI KAFAQAGIKV
RSTRRWEIES LDHAAVKPLV EYKKLYRIWV AHGWSWLQDW VRDGRFRPEF VAGGTVTGRW
VTNGGGGLQI PKVIRRAVVA DPGWRLVVAD ADQMELRVLA AISRDPGLME VAGRETDLYQ
SVSDRAFSGD RDQAKIAVLG AVYGQTSGDG LKNLAALRRR FPKAVAYVDD AARAGEEGRL
VRTWLGRTCP PAAGVGDDAA EEAGIPQDEP ADSPAGGEWA PGYASTDARA RGRFARNFVV
QGSAADWALL LLAALRQACA GMAAELVFFQ HDEVIVHCPE EEAETVVAAI REAAELAGRL
TFGRTPVRFP FTTAVVECYA DAK
//
