ID A0A101W895_9PROT Unreviewed; 638 AA.
AC A0A101W895;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Propionate--CoA ligase {ECO:0000313|EMBL:KUO68528.1};
GN Name=prpE {ECO:0000313|EMBL:KUO68528.1};
GN ORFNames=APF80_07535 {ECO:0000313|EMBL:KUO68528.1};
OS Alphaproteobacteria bacterium BRH_c36.
OC Bacteria; Pseudomonadota; Alphaproteobacteria.
OX NCBI_TaxID=1734406 {ECO:0000313|EMBL:KUO68528.1, ECO:0000313|Proteomes:UP000053382};
RN [1] {ECO:0000313|EMBL:KUO68528.1, ECO:0000313|Proteomes:UP000053382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRH_c36 {ECO:0000313|EMBL:KUO68528.1};
RA Bagnoud A., Chourey K., Hettich R.L., De Bruijn I., Andersson A.F.,
RA Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT "Microbial metabolic network in the subsurface.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO68528.1}.
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DR EMBL; LOEV01000016; KUO68528.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101W895; -.
DR STRING; 1734406.APF80_07535; -.
DR Proteomes; UP000053382; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Ligase {ECO:0000313|EMBL:KUO68528.1}.
FT DOMAIN 8..62
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 69..452
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 519..597
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 638 AA; 69240 MW; 56A39A53ACDC8B45 CRC64;
MTATGSRYHE VYQSWKKDPE AFWGEAARDV DWYKLWDDVF DPYSGQYGHW FPGAECNTAY
NCLDRHVEAG RGDQAALIYD SPVTGTTKTY TYSELTDEVA TLSAVLVDVG VKPGDRVIIY
MPMIAEAVMA MLACARIGAV HSVVFGGFAA SELATRIDDA KPVAIMSASC GIEGAKVIAY
KPLLDKAIEL AKTKPSACIV LQRPQAEASM IAGRDYDWAE VVGLTKSRGR KAGPVAVKAT
DPLYVLYTSG TTGQPKGVVR DNGGHMVALK WTMKNFYNID PGEVFWAASD VGWVVGHSYI
AYAPLLHGAT TLVYEGKPVG TPDAGAFWRV ISQHKVVSLF TAPTAFRAIK KEDPDGSLIG
KYDLSCLRAL FLAGERADPE TLKWAEEKLK VPVIDHWWQT ETGWCIAGNP VGLGLLPVKH
GSPTVAMPGF ELHVLDDNGK RLGANEQGTI AIPLPMPPGC LPTLWGNDKR FRESYLTQFE
GYYSTSDAGY LDEDGYVYVM ARTDDVINVA GHRLSTGQME EVVARHPDVA ECAVIGVADA
LKGQLPAGFL VLNAGVARDH KEIENEVVSL VRNDIGPVAA FKNVMVVQRL PKTRSGKILR
ATMRKIADGE PWTTPATIDD PAILEEIKGV LAGRGMGA
//
