ID A0A102DDR1_9SPHN Unreviewed; 1165 AA.
AC A0A102DDR1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AQZ50_04060 {ECO:0000313|EMBL:KUR79643.1};
OS Novosphingobium sp. Fuku2-ISO-50.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1739114 {ECO:0000313|EMBL:KUR79643.1, ECO:0000313|Proteomes:UP000056630};
RN [1] {ECO:0000313|EMBL:KUR79643.1, ECO:0000313|Proteomes:UP000056630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fuku2-ISO-50 {ECO:0000313|EMBL:KUR79643.1,
RC ECO:0000313|Proteomes:UP000056630};
RA Ruckert C., Winkler A., Glaeser J., Grossart H.-P., Kalinowski J.,
RA Glaeser S.;
RT "Draft genome sequence of Novosphingobium sp. Fuku2-ISO-50 (=DSM 27930), a
RT Novosphingobium acidiphilum related species isolated from a surface water
RT sample of the southwest basin of Lake Grosse Fuchskuhle.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUR79643.1}.
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DR EMBL; LLZR01000005; KUR79643.1; -; Genomic_DNA.
DR RefSeq; WP_067742969.1; NZ_KQ954286.1.
DR AlphaFoldDB; A0A102DDR1; -.
DR STRING; 1739114.AQZ50_04060; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000056630; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:KUR79643.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000056630}.
FT DOMAIN 11..502
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 503..809
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 548..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1165 AA; 126043 MW; 8BBDE86198696622 CRC64;
MSAVKSLAQE VHRLQANQMA AVAPDRTVWL SASAGTGKTQ VLTSRVLRLL LEPGVEPDQI
LCLTFTKAGA AEMATRIGEK LADWVRMPDT VLATHLQAIG APIDQATLAR ARSRFAAVLD
CPGGGLRIET LHAFAQWLLS AFPEEAGLRP GSRAIEDRDR DLLVRDVLVD LLVRAEDSGD
MAFIDALAAL SLRMDESALT RFLLRCAAAT ELWTGPGAWQ SPLRPRINRL LDLPADADRG
LLADCFADAR FPTVALSRCL DALREWGTKS ADGMIAPIAS WIAAPADERA ERWQELARAL
FNDKGEPKYG KNLAKVDPGY ADHAAIVAEA LDATRDLARA LALVDLLEPA LGIGRRFALA
WDEAKTREGI IDFDDQIRAA AALLTERAPA DWIRFKLDRR FDHVLVDEAQ DTNAAQWRIV
LDGLTGDFFA GAGKPRPEET PRTLFVVGDY KQAIFRFQGT SPENFEAARR RVAAQLDELA
LAANEPEFGL LDLGLGRSFR SAQPILRFVD DAIAAIGHRA LGLPHPPEPH VGHDIPGLVC
LWQPVGQEAE PDEDDLPDPG GEETWLSGPD RELAGRIARQ VRQWLDDGFA LSKGRPRRAT
PGDVMVLVRK RGALAGLIVA RLHAEGVPVA GVDRLRLGAP LAVKDLVAAL RFAVQPGDDL
NLASLLVSPL IGWSQEDLLA HGYRRPQAAH GGVRLWDHLR AHENAATHRA MGQLRDLLAR
ADFTSPAGLL TWILVGPWQG RRALIARLGE EAGDPIDELV NAAMAHAASH VPSLAAFLHW
FAAGDGDVKR EAGGQSDLVR VMTVHGSKGL QAPIVILADA TTNPDNALSS PVELDDGGRR
VPLPPLRKEE KPAAIRAAEE AARQAERAEH WRLLYVAMTR AEEALFVTGA LGPRDKGEVP
PESWYGALAQ IMPEAAQADD PIWIRRWQRG ELGPLPPRDA GTAPAAPVIL PPELREAVGP
EPRPLRPLAP SALGEDAAPA APTRPGPGAR VAARRGTLLH RLLERLPEVP AAMRDAAARH
WLARMAGEMP DDERAALIRS ALAVLDEPQW QAVFGPGSLA EVPIAALVGT RMVNGTIDRL
LITSDRVQIV DFKTDRRPPD SLAAIPVAYL RQMAAYVAAL QVIHPGRRVE AALLYTATPR
LFALPDDVLA AQKLGLGPAE ETFSA
//
