ID A0A102DG79_9SPHN Unreviewed; 1158 AA.
AC A0A102DG79;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AQZ49_00140 {ECO:0000313|EMBL:KUR80949.1};
OS Novosphingobium sp. FSW06-99.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1739113 {ECO:0000313|EMBL:KUR80949.1, ECO:0000313|Proteomes:UP000061032};
RN [1] {ECO:0000313|EMBL:KUR80949.1, ECO:0000313|Proteomes:UP000061032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSW06-99 {ECO:0000313|EMBL:KUR80949.1,
RC ECO:0000313|Proteomes:UP000061032};
RA Ruckert C., Winkler A., Glaeser J., Grossart H.-P., Kalinowski J.,
RA Glaeser S.;
RT "Draft genome sequence of Novosphingobium sp. FSW06-99 (=LMG 27919), a
RT Novosphingobium acidiphilum related species isolated from a surface water
RT sample of the southwest basin of Lake Grosse Fuchskuhle.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUR80949.1}.
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DR EMBL; LLZQ01000001; KUR80949.1; -; Genomic_DNA.
DR RefSeq; WP_067612427.1; NZ_KQ954251.1.
DR AlphaFoldDB; A0A102DG79; -.
DR STRING; 1739113.AQZ49_00140; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000061032; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:KUR80949.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000061032}.
FT DOMAIN 11..502
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 525..804
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 954..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1158 AA; 124235 MW; C0F1D156C39AA9E4 CRC64;
MSAVASLAQQ VHRLENNQMA AVAPDRSVWL SASAGTGKTQ VLTSRVLRLL LEPGVEPDQI
LCLTFTKAGA AEMATRIGEK LADWVRMEDT ILATHLQAIG APFDPATLAR ARSRFAAVLD
CPGGGLRIGT IHAFAQWLLS AFPEEAGLRP GSRAMEDRDR DLLVRDVLVD LLVRAQDSGD
SAFIDALGAL SVRMGEGDLT RFLLRCAAAT EVWTGPGAWQ SPLRPRINRL IGLPADADHG
LLADCFADAR FPVAALGRCV DALREWGTKT ADGMIAPIAA WLAADAPVRA TTVAALTRAL
FNAEGEAKYR KNLEKIDPTY TDHAATVSEA LHEAAELGRA LALVDLAEPA LAIGRRFALA
WDEAKTREGF IDFDDQIRAA AALLTERAPA DWIRFKLDRR FDHVLVDEAQ DTNARQWDIV
LDGVTGDFRS GEGQARERPA PRTLFVVGDY KQAIFGFQGT SPREFEAARR RVARELDALA
QAANDPALDL LDLGLGRSFR SAQPILSFVD AAMATIGSDR FGLPAPPEPH VGHAIAGQVC
LWQPVGLAVE ADEDDLPDPG GEETWLSGPD RELAGRIARQ VRQWLDQGYG LGKGRVRRAT
PGDVMVLVRK RGALAALIVA RLHAEGVPVA GVDRLRLGAP LAVKDLIAAL QFCVQPGDDL
NLAGLLVSPL LGWSQEDLLA HGYRRAGMRL WDHLRETEGP VTHATMARLR DLLARADFVS
PAALLNWILV GPWQGRKALL ARLGEEAGDP IDELVNAAMA HASSHVPGLA GFIHWFAAGD
GDVKREAGGQ SDLVRVMTVH GSKGLQAPIV ILADATADPG KALASPVTLD DGAGRSVPLP
PLRKDEKPAR VREAELAAQK ADREEHWRLL YVAMTRAEEA LFITGALGPR DKGEVPEESW
FGALSQVPGA TEQADPIWQR CRTFGVAAAV PPVDAAAARA PAIVLPDDLL VPVGPEPRPP
RPLAPSALGE DAAPAPPTRP GPGARQAMRR GTLLHRLLER LPDVPLAARA DTATQWLARM
AGDWSGDDRD ALVRAALAVL DAPEWSAVFG PGSLAEVPIA ALVGPRLISG TIDRLLISAD
AVRIVDFKTD RRPPAAIADI PGAYLRQMAA YVAALRVIHP GRRVEAALLY TAIPRLYALP
EAMLPMQKLG LGDAEETF
//
