ID A0A102WXD3_9BURK Unreviewed; 340 AA.
AC A0A102WXD3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=DF011_13200 {ECO:0000313|EMBL:RQQ13490.1}, WI38_10320
GN {ECO:0000313|EMBL:KUZ92527.1}, WJ33_09550
GN {ECO:0000313|EMBL:KVG52908.1}, WJ35_08170
GN {ECO:0000313|EMBL:AOJ75045.1}, WM16_20000
GN {ECO:0000313|EMBL:KWK71001.1};
OS Burkholderia ubonensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=101571 {ECO:0000313|EMBL:KUZ92527.1, ECO:0000313|Proteomes:UP000065521};
RN [1] {ECO:0000313|Proteomes:UP000064029, ECO:0000313|Proteomes:UP000065504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSMB2036 {ECO:0000313|EMBL:KVG52908.1,
RC ECO:0000313|Proteomes:UP000064029}, MSMB782WGS
RC {ECO:0000313|EMBL:KWK71001.1, ECO:0000313|Proteomes:UP000065504}, and
RC RF32-BP4 {ECO:0000313|EMBL:KUZ92527.1,
RC ECO:0000313|Proteomes:UP000065521};
RA Sahl J., Keim P., Wagner D.;
RT "Expanding the genomic diversity of Burkholderia species for the
RT development of highly accurate diagnostics.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AOJ75045.1, ECO:0000313|Proteomes:UP000243680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSMB0783 {ECO:0000313|EMBL:AOJ75045.1,
RC ECO:0000313|Proteomes:UP000243680};
RA Sahl J., Wagner D., Keim P.;
RT "Diversity of Burkholderia near neighbor genomes.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RQQ13490.1, ECO:0000313|Proteomes:UP000274995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bp8958 {ECO:0000313|EMBL:RQQ13490.1,
RC ECO:0000313|Proteomes:UP000274995};
RA Hall C., Sahl J., Wagner D.;
RT "Comparative analysis of Burkholderia isolates from Puerto Rico.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013420; AOJ75045.1; -; Genomic_DNA.
DR EMBL; LOTN01000021; KUZ92527.1; -; Genomic_DNA.
DR EMBL; LOXM01000283; KVG52908.1; -; Genomic_DNA.
DR EMBL; LPLU01000104; KWK71001.1; -; Genomic_DNA.
DR EMBL; QTOC01000008; RQQ13490.1; -; Genomic_DNA.
DR RefSeq; WP_010091439.1; NZ_QTOD01000012.1.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000064029; Unassembled WGS sequence.
DR Proteomes; UP000065504; Unassembled WGS sequence.
DR Proteomes; UP000065521; Unassembled WGS sequence.
DR Proteomes; UP000243680; Chromosome 1.
DR Proteomes; UP000274995; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 2..73
FT /note="Winged helix-turn-helix transcription repressor HrcA
FT DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF03444"
FT DOMAIN 106..323
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 340 AA; 37312 MW; 118B8239E02C7250 CRC64;
MLDPRARTLL KTLIDRYIAD GQPVGSRTLS RYSGLELSPA TIRNVMSDLE ELGLVSSPHT
SAGRVPTPRG YRLFVDTMLT VETPIDAEAV ARQVQTTLQA GEPQQKVVAA AASVLSNLSQ
FAGVVLTPRR SHVFKQIEFM RLSDKRILLI IVTPEGDVQN RMLATPRDYS PSQLTEASNY
INAHFAGLSF DEVRRRLRDE IDQLRGDMTA LMHAAVTAST EVPDTEDTVL ISGERNLLEV
ADLSSDMARL RKLFDVFDQK TGLLQLLDVS SHAQGVQIFI GGESTLVPIE EMSVVTAPYE
VNGQIVGTLG VIGPTRMAYN RVIPIVDITA RLLSLTLSQQ
//
