UniProt: A0A103E7J5

Database: UniProt
Entry: A0A103E7J5_9BURK

LinkDB:  A0A103E7J5_9BURK 
Original site:  A0A103E7J5_9BURK

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Ontology (8)   
   GO (8)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (54)   
   InterPro (31)   
   Pfam (12)   
   PROSITE (5)   
   SMART (6)   
All databases (64)   

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ID   A0A103E7J5_9BURK        Unreviewed;      4170 AA.
AC   A0A103E7J5;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KVE29560.1};
GN   ORFNames=WS67_04695 {ECO:0000313|EMBL:KVE29560.1};
OS   Burkholderia singularis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=1503053 {ECO:0000313|EMBL:KVE29560.1, ECO:0000313|Proteomes:UP000062788};
RN   [1] {ECO:0000313|EMBL:KVE29560.1, ECO:0000313|Proteomes:UP000062788}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TSV85 {ECO:0000313|EMBL:KVE29560.1,
RC   ECO:0000313|Proteomes:UP000062788};
RA   Sahl J., Keim P., Wagner D.;
RT   "Expanding the genomic diversity of Burkholderia species for the
RT   development of highly accurate diagnostics.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC       family. {ECO:0000256|ARBA:ARBA00029443}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KVE29560.1}.
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DR   EMBL; LOWA01000013; KVE29560.1; -; Genomic_DNA.
DR   RefSeq; WP_059513556.1; NZ_LOWA01000013.1.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000062788; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 2.
DR   CDD; cd08953; KR_2_SDR_x; 1.
DR   CDD; cd19531; LCL_NRPS-like; 2.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF14765; PS-DH; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000062788};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1005..1080
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2064..2139
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2160..2589
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3798..3873
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4170 AA;  450825 MW;  9378451F5123246F CRC64;
     MNHRLPHFQA DDAPTPLFDA NADGSFTSPV LPATAAQRRL WLVENGDVRA ATYNVPAAFK
     LTGRLDGAVL EQALAFMQQR HPALRSRFHT HDGELRIALA STLAAFARQD ISVLDPEARQ
     AAADRLCASE ADHVFDLAHE APLRSLLIKL AENEHVLFVN VHHIVFDDWS VRIFFRELGV
     VYHALLSGAD PELPAVDYAA AVAQTVTDDA RCARARQYWK AAMSDAPTLH KLPTDRPRPS
     EQRMLGAVSK HVFSRVLAER MRKLCRSAGV TPYMLGMAAF SALLHRYCGE DQIVIGSPFA
     NRSTEAQQNL IGFFINLIPL RVRFDDRVNF IDLLTQVRES LLDAFENAAL PFDQIVEAVR
     PVRSASHAPV FQVMFDYLKG SGGMLALDDV EVQGTLVHTG TSKYDLTVSM EETPDELAAI
     VEYDTDLFDA STITRMMTHF ERLLESLLAS PGAAIAEAAL LPAAELARVR RFTRPDEPLE
     HIPFLPIPQR FRDAVERAPH AQAVVHDEVR LTYDMLDRRS DALANALRMR GVTKGSRVAS
     LLTYSDKLIV SYLGILKVGA VYLPLDPADP RRLEKIEDAA PVALVSTRRD HASLGAQAAV
     VAVLLDDVLE GAMLADAPRM DLPALAENDP AYVIYTSGST GKPKGVEVSH GSLNASYHGW
     HRAYRFGKPG HPVTLQLAGM TFDLFIGDVS RTLACGGKLV MPPREWLLDA ARLHALMLAE
     HVSFGDFPPV ILRELIRHCQ ENGVRLDMLD TLVCGADVWF GHELHAARAL CGPHARVLGS
     YGVTEAAIDS SYFDPDLHEL APGSVVPLGR PLPSCDLLIV DPLLQMTPIG VPGELLVAGP
     AVATGYLGNE ALTAQKFLRG RIGDDARVIV GEGDTRFYRT GDICRFLDDG TIDFLGRRDN
     QIKIRGFRVE LGEIEGVLAA HPQVRQCAIV VRDEASGDPM LAAFVVSHLG VDELRGYLRG
     HLPAHMLPAV IEPLDVMPLT PSGKIDRNRL KTWTLSASDV PEQQQAATDV ERRLLALWQE
     LLATRVPGVH ENFFLCGGHS LAAARLASRI NQAFGLDLSI SSIFNHPTVA EQARLVEQRA
     SRIATGDAPH APLAMPSKEV AEDARLLSYS QQSLWLAAKR QPDDFSYNIP MVWRFDGPLN
     SPALEQAVND VAARHDALRM VFSTHVESLV GSDGKSLQEP VQTLCETLPI RLRRIAVAAP
     EAANLPGLLQ DEHARAFDLH AGPLVRTALF EIGPDRHVFS VTIHHIVIDG PSFGLFWRDL
     QTAYNARAAG DVPVWGRPVR RYADFVSLQR QQLHGESARR QLHYWRDRLR DLPAAITLAH
     SVDAQAAHAG SPQSLTFELP AALAAGIAAL AQRTRCSPFI VYFALFAAAL REQTGDSDFA
     IGTPVSLRPQ HGFDDVLGFF ANTMPLRMRF DGLTTFDRVL RYVREHCLHL YENSGIPFEW
     LVRELNPPRA PGRNAVFQTL FSCEFDDAGL QLANIDARAL PIDIYSAKLD LEMAVHATGG
     RVLCHWMARP GSFDADALNS MQRHFLNAVR AALRPDVFSS PLDASPSLPA GYAAIPSGPA
     NDLYTLFARS VGPFADNVAL DAPALRVSYR QLAAQVAAAA EALTAQGVRR GDRVGIFAGH
     HPHNVTAMLA IACVGAAFVP MDPEHKPQWN RHITNDAALA ALVSHAGTAD AAREFGLPMV
     DLDALSACGQ IAQWVLPSRD AYPDDCAYVI YTSGSTGLPK GVAVSHRSVC RNVLAMTDIM
     GVTPRSRIAQ YVSPVFDVVL GEIFPALAAG AAIVFGERRR LLPGPALIDW LTQQRISHWW
     IVPSALAMVP EAELPALGVI IVAGEACPPE LAQRWAKGRR LLNGYGPTEA AIVVSLTDYH
     AERERLILRP MGVAQLHVLD DELQPADVGM AGELFIGGEC VAQGYLGLPA RTAGSFVANP
     FDAGQGGRMY RTGDVARRLD GGAIQFIGRV DRQVKIRGFR IELDAVRAAL MEVPGVQAAE
     ALAQPDGQGQ PLLVGYVVAR CTKTALLDAL RRKVPEAMVP SNVVFLDALP AGSTGKTDLK
     ALKALAANGA PLAVATVPSA PPDASPARTL QRVREIWCTL LERDDIGDDE NFFDAGGHSL
     RAVALHQRMT EAFGDGLALT DVFEYPTIAA LASRLDALRR QRGDAAPTHA HAGIEPGDDA
     DAIAVIGIAG RFPEAPDLAS FWQRLLAGYE AGRPLSDAEL DAHGVPPELY RQAHFVRRFK
     ELEGKADFDA GFFGYSPREA QVMDPQQRIF LELAWQVLEA AGYGDSGRVR SVGVFAGAAF
     NYYLVQNVMP NAERLRLEPG QWLIGNDKDF IATRTAYKLN LQGPALSIGT ACSSGLMAVH
     LACASLRNGE TEMALAGALA LDPDQVGYLY SEGGIMSPDG RCRPFDAAAA GTAAGSGGGV
     VLLKKLDAAW RDGDTVYAVI KGSAANNDGG AKVSYTAPSV AGQAAVIREA LRAAKTPAES
     IGYVEAHGTG TPLGDPIEVR ALAQAFADET ASGALPHGQC GIGSVKGNIG HLDAAAGIAG
     LIKTVLALHH EVIPPSINCH TPNAQIGFDK TPFSVVQRAR AWPRAGAPRR AGVSSFGVGG
     TNVHVVLEEA PRARRAPAHE PPRWHLLPVS ARSQSAMREQ WQRLRRVLPG TRIRDAAYTL
     QLGRTAFEHR GFAVLDEAGD VNEQLNRIDA LPAFERRHAP PVVFMFPGQG SQHPGMGAAL
     YRAGGVFQAE VDRCASMLRE SIGQDIRSLM FDGDASLLKE TRYTQPALFT IEYALALQLQ
     EWAIVPQAMI GHSVGELVAA AVSGMIALPD ALMLVATRAA AMQRQPAGAM LAVLAGSDEL
     ANLNRSGCEI AAINGPQQFV LAGTVDQIIA LEDACIAAGV ACQRLATSHA FHSSLMAGAE
     AEVNRASARI ARSAGRIPVI SNCSGRWLNQ QDLADPGYWG AHLRHPVQFH TGVGTLLDAL
     DQPIFVEVGP GRALGNLIGG WSQLGAPRIV ATLPHARDKR PDMAALLQGV GTLWAQGVDV
     DWPRMHAPGT ARRIVLPTYA FERKRFWLDR PAIAAANASV SASASASSVS HGTGEVPMQC
     EADDGGGRIT VSFMLHERLW FVDEHRIFDG ASVLPGTACI ELVRRAFALK RPDIATAMRD
     VYFPSALILQ DGEQRRMRVR FEPRDDAADF VLESLDETGE GTAHASGRIG RAAFAPVALE
     SPAALCEQWH LAEVDDARAR FAQAFADYGP RWRSVDAVWL GGNAGLARLK LPAAGHGDLP
     AFALHPALLD VASAFLLVCL RPHDESIPFR YESIEMHRPL CGECYSLAVE TAPNVFDVTL
     FAWDEAASRA DVLVTIRGFG RREPARRTRD VTQWCRTVEW IDAPAGRALP AARWLLFGDE
     WAAFAPANSV LIRHDDAFRP LGGNRYGLRA GNKADCERLV AELAARPDTP LHVVYGWRAA
     SAADVDGAFI GLITLLQVLG ARRLDWRVSL VTKGVRAART LDACAGAALA GLLNAVRWEY
     PHIVCRHIDL DDMHDATLAA LQRELSSEPA MLPDVSPDLP SSITLVDGRR EAASHVPLAT
     ASREDVLRDG GVYLITGGAT GVGLELAMHI ASRRRDVGLA LLSRSPHDEN AARFAALEAA
     GARVLRLAAD VADAGQLAGA VQAARARFGR IDGVIHAAGV EASGLIETGT PDAWRRVLAA
     KVDGARHLFD QFAHERPDFV LLCSSLAAVV GGLGQADYAA ANSYMDALAR YWRQRGMPAV
     AVNWDTWAQT GMAVAHAERS RRPSGHGPAL RGLRNREGGA IFELALAHDV PQLVVSKAGF
     AAGPAARMPR RAEQAAVPEP GSVRQALVAL WQELLGVDHV EIDDDFFDLG GHSLLATQLI
     SRVRDQYARC PTLGEFLEEP TIARILRSLG DDTGQTARAD ETVRYCLVPM HKAGAQAPFF
     CIPGMGGNIT QLLPLANALD ADRPVIGLQY LGLDGVHEPH TSVEQIATHY VRCMRSVQPA
     GPYYVGGHSL GGKIAYEIAR QLHAAGDEIG LVAMFDSAAP PYSFVPHQDD FEIASMILGV
     FAYYSGKMEM MAGIDEAALR TASRERLLAF MSERLARFGV VQSQSDTSAI RGLFNVYRAA
     ADFSALYDPP HEPLPIPMML FKATQPLPDG INLPEIRETP AWGWENFTRL PVRTCEVHGN
     HYSCLMGEHV GQIAGALRHA LSAARRTVEA
//

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