ID A0A103ENE1_9BURK Unreviewed; 708 AA.
AC A0A103ENE1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KVE38142.1};
GN ORFNames=WS68_24435 {ECO:0000313|EMBL:KVE38142.1};
OS Burkholderia sp. TSV86.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=1385594 {ECO:0000313|EMBL:KVE38142.1, ECO:0000313|Proteomes:UP000066043};
RN [1] {ECO:0000313|EMBL:KVE38142.1, ECO:0000313|Proteomes:UP000066043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSV86 {ECO:0000313|EMBL:KVE38142.1,
RC ECO:0000313|Proteomes:UP000066043};
RA Sahl J., Keim P., Wagner D.;
RT "Expanding the genomic diversity of Burkholderia species for the
RT development of highly accurate diagnostics.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KVE38142.1}.
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DR EMBL; LOWB01000036; KVE38142.1; -; Genomic_DNA.
DR RefSeq; WP_059570008.1; NZ_LOWB01000036.1.
DR AlphaFoldDB; A0A103ENE1; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000066043; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 305..480
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 485..578
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 614..699
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 708 AA; 75063 MW; F54C4AD0F1AD30E4 CRC64;
MTHPSADETD TVTHERRDKV LVVTIDHPPV NALSASVRRG LAHALDAAAA DAAVAAVLIV
GAGPNFIAGA DIREFGKPPV PPLLPDVCNR IDASGKPVVV ALHGAVLGGG LEIALAAHYR
IATPGAKLGL PEVQLGLLPG AGGTQRTPRL IGARAALDLM LSGRHVAAGE ALALGLVDRV
AQSDDTLAEG LAYVHELLAA GAPVRRTRDA QGLADRVAAQ AALDAARADV AKKTRGLLSP
GKIVDAVAAA LTQPFDEGLR TERAYFAECV ASPQCAGLVH AFFAEREAAK SPEARRSAPR
PLERIGVVGG GTMGAGIALA ALDAGLPVTM VERDDASLAR GRAHVEKVYA GLVAKGRMTA
GDQAARLARL EGSTSYDALA QADVVIEAVF EDMAVKQAVF AALARACKPG AVLATNTSYL
DIDALAASIE RASDVIGLHF FSLAHIMKLL EVVVPAKAGA DVVATAFELA RKLRKTPVRA
GVCDGFIGNR VLAVYRMAAD HMMEDGASPY QIDQAIRAFG FPMGPYQVVD LAGGDIGWAA
RKRRAPTRDP RLRYVEIADR LCERGWFGQK TGRGFYLYPD GARTGVPDPQ VEEIIDAERA
RKGVVPRVFT DDEIVRRYLA AMINEGANVV RERIALRPLD VDTVFVHGYG FPRYRGGPMH
YADTVGLANV LADIRAFARD DPFFWQPSPL LVELVERGEN FASLNRID
//
