ID A0A103Y4Z0_CYNCS Unreviewed; 925 AA.
AC A0A103Y4Z0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=DNA mismatch repair protein, MSH2 {ECO:0000313|EMBL:KVI02602.1};
GN ORFNames=Ccrd_019116 {ECO:0000313|EMBL:KVI02602.1};
OS Cynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Carduoideae; Cardueae;
OC Carduinae; Cynara.
OX NCBI_TaxID=59895 {ECO:0000313|EMBL:KVI02602.1, ECO:0000313|Proteomes:UP000243975};
RN [1] {ECO:0000313|EMBL:KVI02602.1, ECO:0000313|Proteomes:UP000243975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2C {ECO:0000313|EMBL:KVI02602.1};
RX PubMed=26786968; DOI=10.1038/srep19427;
RA Scaglione D., Reyes-Chin-Wo S., Acquadro A., Froenicke L., Portis E.,
RA Beitel C., Tirone M., Mauro R., Lo Monaco A., Mauromicale G., Faccioli P.,
RA Cattivelli L., Rieseberg L., Michelmore R., Lanteri S.;
RT "The genome sequence of the outbreeding globe artichoke constructed de novo
RT incorporating a phase-aware low-pass sequencing strategy of F1 progeny.";
RL Sci. Rep. 6:19427-19427(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KVI02602.1}.
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DR EMBL; LEKV01002649; KVI02602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A103Y4Z0; -.
DR STRING; 59895.A0A103Y4Z0; -.
DR EnsemblPlants; KVI02602; KVI02602; Ccrd_019116.
DR Gramene; KVI02602; KVI02602; Ccrd_019116.
DR OMA; LVRFPQK; -.
DR Proteomes; UP000243975; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000243975}.
FT DOMAIN 749..765
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KVI02602.1"
SQ SEQUENCE 925 AA; 103585 MW; 35606CDA97E0996C CRC64;
MDGDLQEYNK LPELKLDAKQ AQGFLTFFKK LPNDTKAVRF FDRRDYFTAH GENASFIAKT
YYHTTTALRQ IGSGSDAVSS VSVSKNMFET IVRDLLLERT DHSLELYEGS GSNWRLMKRG
TPGNLGSFED VLFANNDMQD SPVIVALVPN FRETGCTVGL GYVDLAKRVL GMAEFLDDSH
FTSAESALVA LGCKECLLPT ELTKSSECKA LYDAISRCGA MVTERKKAEF KGRDLAQDLG
RLVKGSSEPV RDLASAFEFA PGALGVLLSY AELLADENNY GNYTISQYNL NSYMRLDSAA
IRALNVMESK TDANKNFSLF GLMNRTCTAG MGRRLLHMWL KQPLLDVTEI NVRLDLVQTF
VEDPAFRQDL RQHLKRISDI ERLMRSIEKR RASLFHIVKL YQSSIRLPFI KSAMERYDGQ
FASLVKGRYT DHLNYWTNDD HLNKFIGLVE VAVDLDQLEN GEYMISPGYD SQLSTLKNEQ
ESVEQQIHDL HEQTAKDLDL PLDKGLKLDK GTQFGHVFRI TKKEEPKVRQ KLNTLFIVLE
TRKDGVKFTN TKLKKLGDQY QKILEEYKNC QKELVARVVE TAATFSEMVI DESSIQVFEG
LAMLLSELDV LLSFADLAAS SPTPYARPEI TKSDTGDIIL EGSRHPCVEA QDWVNFIPND
CKLVRGKSWF QIITGPNMGG KSTFIRQVGV NILMAQVGSF VPCDKASISI RDCIFARVGA
GDCQLRGIST FMQEMLETAS ILKGATDKSL IIIDELGRGT STYDGFGLAW AICEHLVEVI
KAPTLFATHF HELTALAHEN AGKPSGVANY HVSAHIDSSS QKLTMLYKNC GNPLIMADFV
FIFCDTDYKV EPGACDQSFG IHVAEFANFP ESVKPSEPDD MALGAPRARQ FLKDFSELPL
DKMDLKQALQ EVKRLKNELQ DDASN
//
