ID A0A105B8W0_9BURK Unreviewed; 350 AA.
AC A0A105B8W0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:KWK67195.1};
GN ORFNames=WJ33_16880 {ECO:0000313|EMBL:KVG73247.1}, WJ35_11650
GN {ECO:0000313|EMBL:AOJ75646.1}, WK95_00110
GN {ECO:0000313|EMBL:KVW48144.1}, WM16_27210
GN {ECO:0000313|EMBL:KWK67195.1};
OS Burkholderia ubonensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=101571 {ECO:0000313|EMBL:KWK67195.1, ECO:0000313|Proteomes:UP000065504};
RN [1] {ECO:0000313|Proteomes:UP000064029, ECO:0000313|Proteomes:UP000065504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSMB1346WGS {ECO:0000313|EMBL:KVW48144.1,
RC ECO:0000313|Proteomes:UP000067565}, MSMB2036
RC {ECO:0000313|EMBL:KVG73247.1, ECO:0000313|Proteomes:UP000064029}, and
RC MSMB782WGS {ECO:0000313|EMBL:KWK67195.1,
RC ECO:0000313|Proteomes:UP000065504};
RA Sahl J., Keim P., Wagner D.;
RT "Expanding the genomic diversity of Burkholderia species for the
RT development of highly accurate diagnostics.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AOJ75646.1, ECO:0000313|Proteomes:UP000243680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSMB0783 {ECO:0000313|EMBL:AOJ75646.1,
RC ECO:0000313|Proteomes:UP000243680};
RA Sahl J., Wagner D., Keim P.;
RT "Diversity of Burkholderia near neighbor genomes.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP013420; AOJ75646.1; -; Genomic_DNA.
DR EMBL; LOXM01000046; KVG73247.1; -; Genomic_DNA.
DR EMBL; LPFE01000011; KVW48144.1; -; Genomic_DNA.
DR EMBL; LPLU01000126; KWK67195.1; -; Genomic_DNA.
DR RefSeq; WP_010090334.1; NZ_LPLU01000126.1.
DR OrthoDB; 9771084at2; -.
DR Proteomes; UP000064029; Unassembled WGS sequence.
DR Proteomes; UP000065504; Unassembled WGS sequence.
DR Proteomes; UP000067565; Unassembled WGS sequence.
DR Proteomes; UP000243680; Chromosome 1.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 14..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 350 AA; 38025 MW; 6C5FB967FBC1BFFC CRC64;
MSTTYAFAAT DAQSPLAPFE FQPRALRDLD VQIEILYCGV CHSDLHQARN EWRNTIYPVV
PGHEIVGRVS ATGPQVSRFK VGELVGVGCL VDSCRTCPSC AEGLEQYCEN GFVGTYNGRD
RVSGDVTYGG YSTQIVVDEA FVLRVPDTLD PAGAAPLLCA GITTYSPLRQ WNVGPGKKVG
IVGLGGLGHM GVKLARAMGA QVVLFTTSPS KVEDGKRLGA HEVVISKDEA QMSAHLNSFD
FILNTVAAQH DLNPFLHLLK RDGTMTLVGA PEHDHPSPQV FNLIFKRRRL AGSLIGGIAE
TQEMLDFCAE HGITSDIETI PMQQINAAYE RMLKSDVKYR FVIDMASIKA
//