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Database: UniProt
Entry: A0A105LPB6_9BURK
LinkDB: A0A105LPB6_9BURK
Original site: A0A105LPB6_9BURK 
ID   A0A105LPB6_9BURK        Unreviewed;       522 AA.
AC   A0A105LPB6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   16-JAN-2019, entry version 24.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=WM16_26895 {ECO:0000313|EMBL:KWK67201.1};
OS   Burkholderia ubonensis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=101571 {ECO:0000313|EMBL:KWK67201.1, ECO:0000313|Proteomes:UP000065504};
RN   [1] {ECO:0000313|EMBL:KWK67201.1, ECO:0000313|Proteomes:UP000065504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSMB782WGS {ECO:0000313|EMBL:KWK67201.1,
RC   ECO:0000313|Proteomes:UP000065504};
RA   Sahl J., Keim P., Wagner D.;
RT   "Expanding the genomic diversity of Burkholderia species for the
RT   development of highly accurate diagnostics.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KWK67201.1}.
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DR   EMBL; LPLU01000126; KWK67201.1; -; Genomic_DNA.
DR   RefSeq; WP_059956523.1; NZ_MEAU01000056.1.
DR   EnsemblBacteria; KWK67201; KWK67201; WM16_26895.
DR   Proteomes; UP000065504; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000065504};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      219    353       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      430    499       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     227    234       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   522 AA;  57125 MW;  DF7613675C2168C0 CRC64;
     MNDFWQHCSA LLERELTPQQ YVTWIKPLAP VAFDAAANTL SIAAPNRFKL DWVKSQFSGR
     ISDLARDFWN APIEVLFVLD PKAGMRSAAG AAPAAPRAPL APAGGPAAAV AAIAANVAAA
     APAAPAVVDA PIGAQAAAHL SADDADIDLP SLPAHEAAAG RRTWRPGNGA APAAAGETDS
     MYERSKLNPV LTFDNFVTGK ANQLARAAAI QVADNPGISY NPLFLYGGVG LGKTHLIHAI
     GNQLLLDKPG ARIRYIHAEQ YVSDVVKAYQ RKAFDDFKRY YHSLDLLLID DIQFFSGKSR
     TQEEFFYAFE ALVANKAQVI ITSDTYPKEI SGIDDRLISR FDSGLTVAIE PPELEMRVAI
     LMRKAQSEGV NLSEDVAFFV AKHLRSNVRE LEGALRKILA YSKFHGREIS IELTKEALKD
     LLTVQNRQIS VENIQKTVAD FYNIKVADMY SKKRPANIAR PRQIAMYLAK ELTQKSLPEI
     GELFGGRDHT TVLHAVRKIA DERSKDAQLN HELHVLEQTL KG
//
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