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Database: UniProt
Entry: A0A108C726_9BURK
LinkDB: A0A108C726_9BURK
Original site: A0A108C726_9BURK 
ID   A0A108C726_9BURK        Unreviewed;       339 AA.
AC   A0A108C726;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   11-DEC-2019, entry version 18.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=WM16_24015 {ECO:0000313|EMBL:KWK69287.1};
OS   Burkholderia ubonensis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=101571 {ECO:0000313|EMBL:KWK69287.1, ECO:0000313|Proteomes:UP000065504};
RN   [1] {ECO:0000313|EMBL:KWK69287.1, ECO:0000313|Proteomes:UP000065504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSMB782WGS {ECO:0000313|EMBL:KWK69287.1,
RC   ECO:0000313|Proteomes:UP000065504};
RA   Sahl J., Keim P., Wagner D.;
RT   "Expanding the genomic diversity of Burkholderia species for the
RT   development of highly accurate diagnostics.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KWK69287.1}.
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DR   EMBL; LPLU01000111; KWK69287.1; -; Genomic_DNA.
DR   EnsemblBacteria; KWK69287; KWK69287; WM16_24015.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000065504; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN          32..323
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   339 AA;  36278 MW;  21BDE511F6904DEC CRC64;
     MRLPAPDELR RDLPASVAAR ATVAAGRRQL RAILERRDAR RIVVVGPCSI HDPQAALDYA
     RRLARLANAV RDAFCVVMRV YFEKPRTTVG WKGLINDPGL DGSHRVLDGL HAARRLLADI
     NALSLPAAIE ALDVVTPHYL CDLVSWAAIG ARTTESQVHR ELASGLAMPV GFKNGTDGHV
     DVAVHAMLAS MRPHTFIGID GAGGPALLHS DGNPHAHLVL RGGRHGPNYD AASVAAAVET
     LRAQRLPANL LIDCSHANCG KQADRQLAVL DDVVEQMCAG SDAIRGVMLE SFLEAGAQPL
     GGPLRYGCSI TDPCLGWDAT EDALLRARSR WLARDGRAG
//
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