ID A0A108T226_9BACE Unreviewed; 814 AA.
AC A0A108T226;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=F2Y81_08880 {ECO:0000313|EMBL:KAA5420174.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:KAA5420174.1, ECO:0000313|Proteomes:UP000448877};
RN [1] {ECO:0000313|EMBL:KAA5420174.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5420174.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA5420174.1}.
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DR EMBL; VVYV01000011; KAA5420174.1; -; Genomic_DNA.
DR RefSeq; WP_007215528.1; NZ_VVYV01000011.1.
DR AlphaFoldDB; A0A108T226; -.
DR STRING; 246787.BcellWH2_04347; -.
DR eggNOG; COG3525; Bacteria.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR026876; Fn3_assoc_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF13287; Fn3_assoc; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KAA5420174.1};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..814
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030020042"
FT DOMAIN 644..779
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT ACT_SITE 345
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 814 AA; 91667 MW; D5E4CC291AB4F19D CRC64;
MKKGLSALLL ASLLCASSGC QQNQKEVVNE YNIVPMPNQM TPQEGRFLLS NKVSVVTAGC
TPEVQAIADS LIAQIQLTSG ISLKTSSQEN PEQPDIRFVT EEGMPKEGYK LSIAPNEITL
SASHPNGFFY GVQTMYQLLP PAIYGKATVK RANWSLPAVE VEDAPRFPYR GLMLDVCRHF
STTDYIYKFI DMLAMHKMNT FHFHLTDDQG WRIEIKKYPK LQEVGSKRKE TLIDYYFVNW
PQIFDGKEHG GYYTQEEIKD IVAYAASKYI TVIPEIEMPG HAIAALASYP ELSCRPDTTY
EVTGTWGVFE EVFCPKEETF QFLEGVLDEV MELFPSSYIH IGGDECPKDA WMKCAHCQGL
IKKLGLKDDT TPNAIDGKKH TKEEKLQSYF ITRMEKYLNS KGRNIIGWDE ILEGGLAPNA
TVMSWRGVEG GITAAKAGHD AIMTPSPYAY LDQYQEEPET APTTIGGYQT LKKTYSYNPV
PDDADELVKK HIIGVQGNIW NEYMQSDERR DYQAFPRAVA LAETGWTQNN RKNWNSFRSR
MVEDFERMDA MNVKACRNFF DVNINTHVYD GTLKAVLETF YPDAKIRYTT DGSAPTAKSE
LYTQPFTWEG YIDLQAAAFK NGKMLGKVNG KKLYANLISG KQYTTTPHWG WMSGDIFGEN
DILGADTTTL GLTNGKRGNI ASFTPWVAFS LNEKNNNELV FSVDLEKPAT ISKVIFGTLY
NPAFRVLPAS AARVEVSTNG KEFKEVAQTS YTREYPEHGR KMFTDVLEFT PTEARYIKVT
LKSGGTLRNG IDCRKDSPGD IIPSDLYVDE IEVY
//
