ID A0A108TB08_BACSE Unreviewed; 463 AA.
AC A0A108TB08;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:KWR56595.1};
GN ORFNames=AA415_00904 {ECO:0000313|EMBL:KWR56595.1}, DW668_01845
GN {ECO:0000313|EMBL:RHF77997.1}, DW853_00940
GN {ECO:0000313|EMBL:RHC33770.1}, DW889_03525
GN {ECO:0000313|EMBL:RHB31771.1}, DWV41_07985
GN {ECO:0000313|EMBL:RGW97591.1}, DWV77_02505
GN {ECO:0000313|EMBL:RGW36202.1}, DWY58_06550
GN {ECO:0000313|EMBL:RGR28448.1}, DWY65_00780
GN {ECO:0000313|EMBL:RGR17867.1}, DWZ78_02740
GN {ECO:0000313|EMBL:RHM22096.1}, DXC34_08120
GN {ECO:0000313|EMBL:RGM13402.1}, F9950_01525
GN {ECO:0000313|EMBL:KAB5330404.1}, F9958_05145
GN {ECO:0000313|EMBL:KAB5315513.1}, F9962_04815
GN {ECO:0000313|EMBL:KAB5282882.1};
OS Bacteroides stercoris.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=46506 {ECO:0000313|EMBL:KWR56595.1, ECO:0000313|Proteomes:UP000056419};
RN [1] {ECO:0000313|EMBL:KWR56595.1, ECO:0000313|Proteomes:UP000056419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL09T03C01 {ECO:0000313|EMBL:KWR56595.1,
RC ECO:0000313|Proteomes:UP000056419};
RX PubMed=26768901; DOI=10.1186/s12864-016-2377-z;
RA Coyne M.J., Roelofs K.G., Comstock L.E.;
RT "Type VI secretion systems of human gut Bacteroidales segregate into three
RT genetic architectures, two of which are contained on mobile genetic
RT elements.";
RL BMC Genomics 17:58-58(2016).
RN [2] {ECO:0000313|EMBL:KWR56595.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL09T03C01 {ECO:0000313|EMBL:KWR56595.1};
RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA SanMiguel P., Csonka L.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000261223, ECO:0000313|Proteomes:UP000283310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF05-4 {ECO:0000313|EMBL:RGW97591.1,
RC ECO:0000313|Proteomes:UP000284777}, AF12-7
RC {ECO:0000313|EMBL:RGW36202.1, ECO:0000313|Proteomes:UP000285150},
RC AF25-6 {ECO:0000313|EMBL:RGR28448.1,
RC ECO:0000313|Proteomes:UP000284161}, AF26-20BH
RC {ECO:0000313|EMBL:RGR17867.1, ECO:0000313|Proteomes:UP000283310},
RC AF35-20 {ECO:0000313|EMBL:RHM22096.1,
RC ECO:0000313|Proteomes:UP000284604}, AM25-16
RC {ECO:0000313|EMBL:RHF77997.1, ECO:0000313|Proteomes:UP000283762},
RC AM36-9BH {ECO:0000313|EMBL:RHC33770.1,
RC ECO:0000313|Proteomes:UP000285305}, AM40-34
RC {ECO:0000313|EMBL:RHB31771.1, ECO:0000313|Proteomes:UP000283482}, and
RC TF03-6 {ECO:0000313|EMBL:RGM13402.1,
RC ECO:0000313|Proteomes:UP000261223};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000431177, ECO:0000313|Proteomes:UP000440773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A17 {ECO:0000313|EMBL:KAB5282882.1,
RC ECO:0000313|Proteomes:UP000440773}, BIOML-A2
RC {ECO:0000313|EMBL:KAB5330404.1, ECO:0000313|Proteomes:UP000431177},
RC and BIOML-A6 {ECO:0000313|EMBL:KAB5315513.1,
RC ECO:0000313|Proteomes:UP000467334};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWR56595.1}.
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DR EMBL; WCLP01000009; KAB5282882.1; -; Genomic_DNA.
DR EMBL; WCLE01000007; KAB5315513.1; -; Genomic_DNA.
DR EMBL; WCLA01000002; KAB5330404.1; -; Genomic_DNA.
DR EMBL; LRGC01000003; KWR56595.1; -; Genomic_DNA.
DR EMBL; QSSV01000009; RGM13402.1; -; Genomic_DNA.
DR EMBL; QRTW01000001; RGR17867.1; -; Genomic_DNA.
DR EMBL; QRUB01000004; RGR28448.1; -; Genomic_DNA.
DR EMBL; QSAF01000002; RGW36202.1; -; Genomic_DNA.
DR EMBL; QSBD01000009; RGW97591.1; -; Genomic_DNA.
DR EMBL; QSGN01000005; RHB31771.1; -; Genomic_DNA.
DR EMBL; QSHQ01000001; RHC33770.1; -; Genomic_DNA.
DR EMBL; QRHJ01000003; RHF77997.1; -; Genomic_DNA.
DR EMBL; QRPN01000002; RHM22096.1; -; Genomic_DNA.
DR RefSeq; WP_005657328.1; NZ_WCLU01000009.1.
DR AlphaFoldDB; A0A108TB08; -.
DR STRING; 46506.AA415_00904; -.
DR GeneID; 31798419; -.
DR PATRIC; fig|46506.5.peg.976; -.
DR Proteomes; UP000056419; Unassembled WGS sequence.
DR Proteomes; UP000261223; Unassembled WGS sequence.
DR Proteomes; UP000283310; Unassembled WGS sequence.
DR Proteomes; UP000283482; Unassembled WGS sequence.
DR Proteomes; UP000283762; Unassembled WGS sequence.
DR Proteomes; UP000284161; Unassembled WGS sequence.
DR Proteomes; UP000284604; Unassembled WGS sequence.
DR Proteomes; UP000284777; Unassembled WGS sequence.
DR Proteomes; UP000285150; Unassembled WGS sequence.
DR Proteomes; UP000285305; Unassembled WGS sequence.
DR Proteomes; UP000431177; Unassembled WGS sequence.
DR Proteomes; UP000440773; Unassembled WGS sequence.
DR Proteomes; UP000467334; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00377}; Reference proteome {ECO:0000313|Proteomes:UP000056419}.
FT DOMAIN 159..289
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 370..439
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT BINDING 167..174
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ SEQUENCE 463 AA; 53119 MW; F7EDC28F165A48EC CRC64;
MSGQDHVGLW NRCLEIIRDN VPEQTYKTWF LPIVPLKYED KTLVVQVPSQ FFYEFLEDKF
VDLLRKTLYK VIGEGTKLMY NVMVDKSSRP EKTVNYESTH RTIMPQKQTI DKAIPQIPVP
DLDPHLNPEY NFDTFIEGYS NKLSRSVAEA VALNPAKTIF NPLFLYGASG VGKTHLANAI
GTKIKELYPE KRVLYVSAHL FQVQYTDSVR NNTTNDFINF YQTIDILIID DIQEFAGVTK
TQNTFFHIFN HLHQNGKQLI LTSDRAPVLL QGMEERLITR FKWGMVAELE KPTVELRKNI
LRNKIHRDGL QFPPEVIDYI AENVGNSVRD LEGIVISIMA HSTIYNKEID LELAQRIVRK
VVNCESKAIT IDDIITTVCK HFGLENAAIH TKSRKREVVQ ARQIAMYLAK KHTDFSTAKI
GTLIGNKDHA TVLHACKTIK QLKEVDKSFR AEIEEIQTAL KKV
//
