ID   A0A109FKQ2_9BASI        Unreviewed;      1001 AA.
AC   A0A109FKQ2;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=3'-5' exonuclease domain-containing protein {ECO:0000259|SMART:SM00474};
GN   ORFNames=RHOSPDRAFT_28500 {ECO:0000313|EMBL:KWU46224.1};
OS   Rhodotorula sp. JG-1b.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX   NCBI_TaxID=1305733 {ECO:0000313|EMBL:KWU46224.1, ECO:0000313|Proteomes:UP000062823};
RN   [1] {ECO:0000313|EMBL:KWU46224.1, ECO:0000313|Proteomes:UP000062823}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JG-1b {ECO:0000313|EMBL:KWU46224.1,
RC   ECO:0000313|Proteomes:UP000062823};
RG   DOE Joint Genome Institute;
RA   Goordial J., Raymond-Bouchard I., Riley R., Ronholm J., Shapiro N.,
RA   Woyke T., Grigoriev I.V., Labutti K.M., Greer C., Whyte L., Bakermans C.;
RT   "Draft genome of eurypsychrophile Rhodotorula sp. JG1b isolated from
RT   permafrost in the hyper-arid Upper Elevation McMurdo Dry Valleys,
RT   Antarctica.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KQ954468; KWU46224.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A109FKQ2; -.
DR   STRING; 1305733.A0A109FKQ2; -.
DR   OrthoDB; 2880475at2759; -.
DR   Proteomes; UP000062823; Unassembled WGS sequence.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   CDD; cd06147; Rrp6p_like_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   InterPro; IPR049559; Rrp6p-like_exo.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF08066; PMC2NT; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000062823}.
FT   DOMAIN          271..448
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   REGION          767..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          830..972
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..791
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..868
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..921
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1001 AA;  107186 MW;  09AACADBE0AFF4CA CRC64;
     MADDLQTLLD SLQAALVPPT KTAARLPAAD DLQFERTLSR KLARALDHEQ ERVLSLAQRV
     LDWTSASATT TTPASAVVDA DLIREGVYNP VTERVEPLLE LADDAIDLHL GQGKHRRNHG
     AGALGAKSAH ELELRAKQRD QQQRLPARLL HDSALEKPQL RFTERTRVPI PHVDEAVDGV
     PLWKPLLREK VNAQSASEGG EGGWLATEMY EPKSSYTQTT GTVPPAYTRY THPYAAELAS
     LTPPARFLEK PVPTSRAATT TAAESFSKTP FEWVGDAAAL ERMVDEIRQV GQEETGGKDL
     AIDLEHHDYR SWSGMTCLIQ LSTRKKDYVI DALEPSVRDG LEALNEFFTD PEWVKVLHGA
     NSDVVWLQRD FGLYIVGLFD TYHATKVLGY SQHSLASLLA MYTDFEADKR YQLADWRIRP
     LPKEMLHYAR SDTHYLLSIY DRLRLALHEK AASANSVGDG DPALSPLEEV YRRSIGVSSI
     TFSLPPFDHE TGHFDSGFLL PLAKHGVLKA YSTALAIPTL PLKTGWGPSE GRFEVLRSVI
     RWREQTARDE DESGRYVLSL QGSLQLAEVG AAGGIKDAND VMRVLGGTRG GVSEVARRRK
     DELAAVITET VERVRGNGGL GSAAGGEDVD MDGGAAALAI TSAQLGFPAP EPAVRPIDGL
     WDAEPIASTS RSATTVVSVS VAGTSAFFGG SMAGGEGTGD GRSVIAPVVP VAASSSFFGP
     AKSTTAAAKN KKGKSKARAA DAGSEASIAI RTEAVKRVHD SLVLGGGLGQ SLQPKPIPTE
     NAKSSATPKT DVVLPDASTT ETQPDPPSAL TADHTYVPLS GRIPKEMAPS TLASSTSHVA
     PKPKDSDVIV VSSLKDKPKK RRRQGSEAEP SPADLASPGG ERKPKAKKVK ADSNAGEATA
     STAASASKPK KDKKAKRDPN AAPIVPHDYS TSTSILDADP AASSAAIADK KERKRQAKID
     QLAGAGGGKK KGFEIDLSDF RRAPRVANAP KKANVSRSFA K
//