ID A0A109FMK5_9BASI Unreviewed; 5368 AA.
AC A0A109FMK5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=RHOSPDRAFT_24275 {ECO:0000313|EMBL:KWU47230.1};
OS Rhodotorula sp. JG-1b.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1305733 {ECO:0000313|EMBL:KWU47230.1, ECO:0000313|Proteomes:UP000062823};
RN [1] {ECO:0000313|EMBL:KWU47230.1, ECO:0000313|Proteomes:UP000062823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JG-1b {ECO:0000313|EMBL:KWU47230.1,
RC ECO:0000313|Proteomes:UP000062823};
RG DOE Joint Genome Institute;
RA Goordial J., Raymond-Bouchard I., Riley R., Ronholm J., Shapiro N.,
RA Woyke T., Grigoriev I.V., Labutti K.M., Greer C., Whyte L., Bakermans C.;
RT "Draft genome of eurypsychrophile Rhodotorula sp. JG1b isolated from
RT permafrost in the hyper-arid Upper Elevation McMurdo Dry Valleys,
RT Antarctica.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KQ954465; KWU47230.1; -; Genomic_DNA.
DR STRING; 1305733.A0A109FMK5; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000062823; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Hydrolase {ECO:0000313|EMBL:KWU47230.1};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000062823}.
FT DOMAIN 5135..5356
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4432..4984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4465..4479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4489..4505
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4516..4541
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4546..4605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4614..4628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4629..4645
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4646..4678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4679..4717
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4781..4800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4801..4820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4848..4868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4915..4929
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4968..4984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5368 AA; 584549 MW; B388984160402019 CRC64;
MDTDDPPPAA AAAVESSSPL AAPPPLWDLQ HGARFFLQRL RVLELTQTQP TLTLKPDAPP
FQLGWKPLVP IDDLSSLIAV IDSQYRPTGL SVQINESLTV DQTRRNLLAA LARLALDPAL
TIEVIIAFRP IAVALIGRWI EALGLGEEGQ WRQGQPGVEM AAGERNAVNK VWRAIVRSLP
ILGDQVMPFL RLLLRHPLLA GGPPLPDPAA PDYQQQLGPA LLTLHSLIHH LPSLPAISQW
SLPQHVEHLM KTHEHRGIRL VAWRIVRAWL GLFAGTGEKL KRKWVWQLPD DLSEEAIEDL
PAAPWTPYPE HLVAEYTERF GPDSASPHDA DDLVPIGFSE EVVAPEGEEK TCRLVEGGLE
VLVRQRGADP WILHSLESAR MQDEQARLEH YLAEFEIGST PLLDQPEIGR TVVSVSNVLA
FREGLIPSLA SPSASAPSST LSLSHAAAPA ASPVNTAPEV FVETAAHANL LRALASNVIH
REPTLVTGTA SSGKQSAVLH LWDLFHAGGA DGRPTREAKR RGLVVINMAD RSLDSKSLLG
SLSSAPSSSS SSTSTAGAGQ FTFVEGPLTR AVRQGRWTLL LNIDQAAPEL LSVIKVVAER
MHTAASVRRE QSLAYGGIGA EEQDGGVGVR VGGGEGRWVK AAEGFMLFAT RSLPPSSLLD
LATPPPANFF ASHFLSEAVL APLSGEEVGQ IVQGRYGAQL GRVEGLAALL VSAWEAVREA
AHRAKDAAGG ASGGTKREVG VRDLLRWCRR VAHLLPNGMS LPSLAANPTL QEEVFVEARD
VFLGSLILPP PVVAVAPTAA VAVDGESAEA GPSAVFPRDR FSVIARSLAS SLGLSDERAE
WALRRRVPDL VLPTIDTSSG LAPSSSGLSH SVKVGRVSLP YSAPSKRTSS SRPYALTKPS
LLLLEKLAVC LSLSEPVLLV GETGTGKTAA VGYLAELMGK RLTALNLSNQ TEAGDLVGGF
RPIDEVEEAR RAASELLNRF VELFGATFSL TRNADFVAAV RKAFDKKRYN RLVDSFRQAN
KMAASRIVST PDATAEDASE QAQRKRRKVD GAKAQLVERW KDFMTSVGDF EHRHVLSTGG
KGKAKFVFSF VEGPLAQAIR NGDWVLLDEV NLASSETLES LSTLLQSPDS SLVLTERGEL
EPIPRHPEFR LFACMNPATD VGKRDLPAGL RAKFSELWVP PPDEDRDALR TIVEGYIGRV
AVSDRQVVAD VAELYSTIKS LAMRAQLADG QNTPPHFSMR TLARALSFAS DFAPTFGLRR
SLYEGFVMAF TMLLDERSQD VVRGLVDKHI VQQAKNPRSL MERVPTKPPS FGDALRIHHY
WLEQGPQEPE EPEDYILTPS VQAKVCDLAR AVLTRKVPVL IQGPTSAGKT SVVEYLARRT
GHRFVRINNH EHTDIQEYVG TYVSDPKTGK LVFQEGVLVR ALRRGDWIVL DELNLAPTDV
LEALNRLLDD NRELVIPETG EVVRPHPHFM LFATQNPPGL YGGRKVLSRA FRNRFLEMHF
GDVPKEELKV ILERRCRIAP SHAERTVNVF LELQRRRQAG RVFEKQAFAT LRDLFRWGGR
GPVETIQQLA EDGYMLLAER ARRSDDKQTV KEVLEEVLKV TIDEEHLYDF DRLPSLNLPV
PPQSADLVWT SAMRRLYFLI AASLQRHEPV LLVGETGSGK TSVCQALAHA LGRGLHIVGC
HQNTETADLL GGQRPLRNRA ALQAGLAVEA QNILSSAGHD AASPDFEQLV EQVEALATDD
ARALADRMRA TTALFEWHDG PLVQAMRGGD LILLDEISLA DDSVLERLNS VLEPSRTLVL
AEKGGRDLDD IRVVGSAGFE ILATMNPGGD FGKKELSPAL RNRFTEIWVP AVDDVADLLH
IIRSRWSAAH RSELNAFGSR IIEFGQWFAQ QTGQKGGLGI GLRDILGWVD FLNVSASKQH
ERGALPLVDA FCQGALMTVV DGLGALPVAS GLSREGLQNL RHSCWRVLEQ LVSPSIAPEA
VPLDVVDDAD RFSIGPYGVS KGPAPPSSVG YTLLAPTTRL NAMRVVRALQ LPKPILLEGS
PGVGKTSLVT ALSAATGHPL VRINLSDQTD LMDLLGSDLP VEGGKSGEFA WKDAPFLAAM
QSGDWVLLDE MNLASQSVLE GLNSCLDHRG TVYIPELDRT FSRHPEFRIF AAQNPLGQGG
GRKGLPKSFL DRFSVVHMEE LDSSDLRAIA EALFPTVDTA ILERMIAFNQ RVHEETTVGR
SFGMEGSPWE FNLRDVLRWL SLVQASSGFD AHRFQPLEYV RLLYLQRFRN RADREHVARI
FAGIFGTVIE PDEQPWVAVT ADSVQVGHSL YPRADDGIAL QRAGFTIPLR RSMHQPLEAL
TKCLEMGWLS ILTGPRGCGK STLVRQVAAL GGRRLREFAM NAEVDTLELL GSFEQADRFR
DLDGIVRDII ETLKHAVDVQ LHSQGTSALY DSLATLRQLR LRLAEEAAEL DLRELGEGVQ
RILTDPVVAG LQATKDLETR LAGALSSAES AVAAARFEWV DGPLVQAMKN GDWLLIEDAN
LCSPSVLDRL NSLFETGGRL QLAERGPVNG EIQIIAPHPD FRLVMTLDPR NGELSRAMRN
RGIEIAMLES ASPNQLQLKT SQRAIDAFRE PSVSDLALLS RLWTPNPSAE TDQAFVAHLV
SKLAPTRFAL AARFLRANAF AEHTDSTVAG LRELVRHPLV FSINTCKRRF ANTREVPSKV
LLEQPIDVSL VPLFAVVESE ASNLQSAALD VLVKVFSATV NDPGSVSAAG AKALKSLSVW
DQSELAANGR FKLDENMSTV AGLFPLHRAL VALIVAAVAR LADRPEAVTI TTFAQNLTAL
DDELVAVTAS PLLDISTIQR VIAWISEAIE SSPEPVQDIL QDAVSRLQPI RQALALTSGE
AMESIWRLAL PYKPTRASLA DAYRTLIRSL DAAAVPDPAV FDLALEVAVA LGVPQNDVAG
VRDQELMRVV QHLVARLAAA KPKEPETDDA VIAMARASNA VSYLTIDLAA IAATSKNENM
VYALAALREI ARSGRVITLR EILPQHQLAA WPQDAKQDVL GARFAAYTEW AQHLAQGLNE
NYGSVEADDM LRPALLRKVI EIRRGERPSL GRLDSQAAAL ASTARAQVAA ISVDLGSREE
QLRSILLALI ALTVTAASDE AESETDTDLV TYQGLQRRIE SSEVVHRAAD RYLDVSEATL
FGPTFEGTGV AAGFVAFGQF LWHLYVPNLP LDPAIGAQVH SQYLARRLAS VSASLDVVLL
EEAASSGNAS NAKAARLQSD LENLRRESSS AGSAPIEREI DLSLLASLFA ELRSFEDQIL
SEALVRGLLS DLRSTNGPAA TMAARVESMR RSIDTLLRRL DHAYGRMSDI LTPIRLALSV
VKIGFSLLAA HAKSAAAAAT DVPYRHLAER LTSFPSVQAT DNIFQEELPL SLKQGEAPLP
PAQATLLQIA ALATAVDRDT CQRDDVVLRL TQLYERMHHL WATDRRHDEE AAEAAASLYK
AKVDLHEVKT DEEIEAAEFA ELFPAFDNVD AAPTSSPSTA PGTTSARFIQ SGDQDLLAQL
HNSVFGNPTL TGDNSPARVF ERLRVAGLDR LLPRIYDSLD DGLDFNSAAY RVRALVELTR
ALKPTDAVEA PHHDFYNGAN VPETSKAVPV LNALIARLSV LIDKWPEQMV LHGLRDRCRA
VLDLTADAPV ALVLTNVEQL LQQTEDWEKF ADREHSIATD RSALTTLIVD WRRYELACWA
QLLSTVETRF GASAHEWWFR IYDAAIRSAP GLDSEAETSA EGAEAFYRDL VSLVNTFLSS
SSLGQFQPRL ELVLSFAKFA RRLGSSPHAL EELGAGVKSL SRVSDLLYNV HGFHAQYASR
IATHLASERG RIDKEVQQVV KLASWKDINV VALRASAVRS HHQLFKSVRK LRTVLQKPAS
DFFQSPEIAQ HENMPSSSNA LETVASTVSL PPLPAGVESS NDAVHLVKLE QTASRLHHLL
SASICPYVDG DRASSLESFS HDVISTAKDL RDTPLGPEEG REQRTKSLIE RKRRAWRDLL
NELKRIGISP SPSPRAVERL EDTAHTFGIA PSDPLLELTD QSLGGDLRSR IERVDGYYFK
ALAMLPELRA LPAAHHGDVR TADIQRALGH IQSVLSAALE HRNLLMPAAA ATLRIDAIAE
RLDSSLSSRS ATNGRQLLVG VQTRVCSAIA AFEEARASLR DHRTATACGE DKGAAAFAAR
IESALASLSQ LQTRVCTALD VRGDPAATAL SSSSDIDLCD EAENAIRLAQ DLINNLPNEA
TLRYLIEPLA GYLSSLVDSK HATTAAGAET ATLQDAKRAH DDLISAILIV AQELKKAAEA
GSAVQGDGEL TDGAVLHGSR TYRAVLSALR PSDVLAKLEY LNDNVRLLLA HDAPVEAIVS
LVERVKPFLS MYRELCAAHL ASFFSWHKSM LKLNHVLASI LKELAADGFC RPAESDGKNG
AEDAADGKTT EGTGMAEGSG AKNVSNEIED ESQLEGLQSD VPQEKREDEE EPQDGDDDAV
EMNMDFEGDL EDRGDGEKES GDEEDDDEEP DQEEPEEQIA DVDPLDPSSV DEKMWGDDEP
PSENKDGKTD EVNQEAAKST GEAEMGAKED EQSADKPKAD ESTDAADSEQ PEPQNADGED
KDAAPQDDAG GDEPEDEPAE GDEAEADADK GDRINEPMDE SDKLDLPEDM KLDEEDDRAS
AGGDEGDIDG DLDLPDDLPD MAEEGPEGDD DDDGDRQNEL DKDATDAADG EAEDDTVLPN
NDAAPEDEHA SAAQDEQVDV DQADGGAEDG EAGGEGQQDG SALENDPNVK ADSTQRTGDR
SSAKQSDEAE ISKDKENADA EEAEAREDED DSAPPMATSA DGTGPTKQRS QHDARAESKL
DPSSQRDEGA RPPQRSLGDS LQNWRRRLEE IGDLAQPEEP QEAQTRPADQ DGAVEYVQDG
DEQEADEQAL GPANEDQVKK LEQLHLGEET APADEMPLDD ESPAEPSDGT APQPQASTVD
LKGSTLTEAD AKAVAASEMQ RDDPMSLDAL SADEDDVDVE RADADKHGST LAAPVDPEED
MAVEQAMLRW RSGDEQSLTA DGVWRLYESL TRDLSFALTE QLRLILEPTL ATRLKGDYRS
GKRLNMKKII PYIASEFTKD KIWLRRTRPS QREYQVLIAI DDSKSMADSH SVHLAFQSLA
LISRALTRLE VGGISVSRFG EDVDVLHPFE AGSVSDEAGA KLIEKFTFSQ RSTDVRLLVE
RTLAQLAEAK DSARSGKSSL QAGDLWQLAV LISDGMCQDH DKLRALLRKA AEQKVLFVFV
VVDSLHGRAR DSADQAQEQD PNQHSILAMK SVSYAVGANG RLELKMDRYI DSFGSVFPHY
LVLRNADALP DVLSTLLRDF FASTAADR
//