ID A0A109IH98_9ACTN Unreviewed; 390 AA.
AC A0A109IH98;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=[acyl-carrier-protein] S-malonyltransferase {ECO:0000256|ARBA:ARBA00013258};
DE EC=2.3.1.39 {ECO:0000256|ARBA:ARBA00013258};
GN ORFNames=GA0070623_5213 {ECO:0000313|EMBL:SCG80796.1};
OS Micromonospora rifamycinica.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=291594 {ECO:0000313|EMBL:SCG80796.1, ECO:0000313|Proteomes:UP000198226};
RN [1] {ECO:0000313|EMBL:SCG80796.1, ECO:0000313|Proteomes:UP000198226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44983 {ECO:0000313|EMBL:SCG80796.1,
RC ECO:0000313|Proteomes:UP000198226};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00000936};
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DR EMBL; LT607752; SCG80796.1; -; Genomic_DNA.
DR RefSeq; WP_067313080.1; NZ_LT607752.1.
DR AlphaFoldDB; A0A109IH98; -.
DR OrthoDB; 3248271at2; -.
DR Proteomes; UP000198226; Chromosome i.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SCG80796.1}.
FT DOMAIN 5..294
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
SQ SEQUENCE 390 AA; 39965 MW; 29AD69E1C9D4D5D2 CRC64;
MLAVLSPGQG SQKPGFLTPW LDLRGAESRL RWWSASAGVD LVRLGTEADA DEIRDTARTQ
PLLVASALLA AEQLPLHDVD LVAGHSVGEL AAAALAGVLS AETVITLAGV RGREMADACA
LEPTGMAAVL GGDPDEVLAA LATHGLHPAN RNGAGQVVAA GALDALDKLA AEPPAKAKVV
RLKVAGAFHT PYMATAEQAL AAVAAGITPS APARLLLSDL DGAVVSRGRE FVHRLVRQVT
APVRWDLCMH TLAELGVTGL LELPPAGTLA GLAKRELKAT GVPEIVTLNT PRDLPAARDL
IARHSGPPAD RPAPAPSRVV VAPAVGSFTP AEGLVEGARL STGQVLGQVA TRQGPVEVTA
HDSGPLTEWL AHHDDPVAPG RPIARIGGHA
//
