ID   A0A109IM32_9ACTN        Unreviewed;       738 AA.
AC   A0A109IM32;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SCG55073.1};
GN   ORFNames=GA0070623_2307 {ECO:0000313|EMBL:SCG55073.1};
OS   Micromonospora rifamycinica.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=291594 {ECO:0000313|EMBL:SCG55073.1, ECO:0000313|Proteomes:UP000198226};
RN   [1] {ECO:0000313|EMBL:SCG55073.1, ECO:0000313|Proteomes:UP000198226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44983 {ECO:0000313|EMBL:SCG55073.1,
RC   ECO:0000313|Proteomes:UP000198226};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; LT607752; SCG55073.1; -; Genomic_DNA.
DR   RefSeq; WP_067305358.1; NZ_LT607752.1.
DR   AlphaFoldDB; A0A109IM32; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000198226; Chromosome i.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          65..375
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          405..715
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   738 AA;  77291 MW;  931E4EDAE73AA5BE CRC64;
     MGGRPVTVRL ARWSAEHPWR AIALWVVFVA VCFVGGNAAG LNEATGADQA IGESGRADVI
     VTEGRFTDPA VENVLITPRT GTLDRAAAQA AATDATERLR QVTGVASVGE PVPSRDGAAL
     LVPITMAGDP ETAADRVQPL RDATAAAQAA HPQLRIEQVG GPSINQALDD TLGRDFKRAE
     LLSLPVTLAI LIVAFGALIA AGVPVLLALS SVAAAMGLST LASHLVPATD TTASVILLIG
     MAVGVDYSLF YVRREREERA KGRSGLDAVE IAAETSGHAV VVSGFAVIIS MAGLLLADDV
     VFSSLAVGSI LVVAVAVTGS LTVLPALLAK LGRWVDRPRV PLLWRLTAPR TGRHGQPARP
     RFWPAVLRPA LRAPRATLIV SVGLLLALAA PALGMKLKFP GMEDLPRTTP AMQAYDRLTA
     AFPSAGTSHT VAVRAPADQA DQVHAALTGL ARSAAADPLF APVEADGPKI EVSADRRVSV
     LQVATPYASR DDRSVRSLHE LRDDLLPAAL RGVPGVEYAV GGGVAASEDY ARHIREKLPL
     VMAFVLALTF LVMTWTFRSV VVALTSILLN LLSAGAAYGL LVLVFQGSWA QDLLGFTSMG
     AIVSWLPLFL FVVLFGLSMD YHVFVVSRIR EAVRAGRSNA DAVAYGITSS AGVVTSAAIV
     MVGVFAIFAS LSTIDMKQLG IGLAAAILLD ATIIRAVVLP SVMTLLGEAN WWAPRFLRGR
     GRPATPPAEP TPELVGAY
//