ID   A0A109IQ22_9ACTN        Unreviewed;      1162 AA.
AC   A0A109IQ22;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SCG66885.1};
GN   ORFNames=GA0070623_3233 {ECO:0000313|EMBL:SCG66885.1};
OS   Micromonospora rifamycinica.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=291594 {ECO:0000313|EMBL:SCG66885.1, ECO:0000313|Proteomes:UP000198226};
RN   [1] {ECO:0000313|EMBL:SCG66885.1, ECO:0000313|Proteomes:UP000198226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44983 {ECO:0000313|EMBL:SCG66885.1,
RC   ECO:0000313|Proteomes:UP000198226};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; LT607752; SCG66885.1; -; Genomic_DNA.
DR   RefSeq; WP_067300256.1; NZ_LT607752.1.
DR   AlphaFoldDB; A0A109IQ22; -.
DR   Proteomes; UP000198226; Chromosome i.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   Gene3D; 3.90.820.10; Structural Genomics, Unknown Function 30-nov-00 1gh9 Mol_id; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR005153; MbtH-like_dom.
DR   InterPro; IPR038020; MbtH-like_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF03621; MbtH; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00923; MbtH; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   SUPFAM; SSF160582; MbtH-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
SQ   SEQUENCE   1162 AA;  124522 MW;  C9AAEBDE1805F9C8 CRC64;
     MSADPRHVVV NDEGQYSLWP ADRTVPGGWT PVFTGPVERC LEHVAGHWTD LRPASLRTTA
     GGAEHDVRPE PATVGVADRD LRPEPATVDA ARSVATGPRR PFGRTPLHVL VDEALAADPG
     RIAVRFAGVE VTAGDLLARV RHTARVLRAH GAGPETPVAV LLPRSVDAVV AILAVLAAGS
     AYLPLSVHDP VDRRARILAD AGDPLLLTGP EYRGHLPAGY PATVLDVTDL PDTLGDDGDG
     GCRVENLAFI MYTSGTSGAP KGVLGTHRQL VNYVDWCARE FAFQPRERAV LHAPLYFVGS
     VMTLFTALVA GWELEVAPEP VAFDDLITLT AAAPCGFLKL TPSHVRAMTA LGGVDDVARQ
     VMIGSEPLYL TPEFDRWISN SPKSGFGNHY GMSETVGATW YWIGTDRTVG RRLPVGAPIP
     NAEVHILDED GLPVPVGRTG EICLGGAVIG RGYHGQPVLT AQRWIPHPAG GGARLLRTGD
     LGRLAADGVL DVLGRADRQV KIRGQRVEPP AVEDALRRCP GVAEAVVIAE PDGHDLRLVA
     YLRSDEEQRP TEAQLRAHAA GLLPEASVPS RFRYVAQYPL TPNGKVDTRR LPTVPTVRPE
     LDTPYAAPSG DLETAVAAVV AGVLRVDRLG VDDDFFALGG DSMQVVEVVT RLDEELGLPV
     GIADLFDRRT VRALAAGMDG HHPTTASTPV APTVEPADRP ARTDVGPAVV TDPEIQARFA
     GASTGSAPLT WGQAAMYRPM QWFGEASRDF NIRRVLRLAA PVPVERVTAA WSALVLRHQV
     LRTLTTDDAD GPRQHLRADG TYPPLVRDTT AEALPEAAEA AAVELAGSAF NLDREWPVRW
     ALLRVDGLVE AVAVAASHVS LDGWSLELLL AELRTLVEGG RTLPAPGWQP LDQAGYEASP
     AGQRRARQSL AYWRDRLPMV PQRIFDGPEQ DAAALPVVTW RMESSAVAVA AAVLAQRTGA
     SSSTVVLTAA LLIQAALTGR DRAVVKLIAG NRNTPRQREL ATGIAQNALL VFDVGDGDVE
     DAVRRCYRDS TESYFHATYP PDALDDLIRA EGAQADLSVY FNDSRMGRDF DVPADPPDRA
     TLSDLAAQTT VRQIAAVARH DMTFFLAMPH LADGCALHLL ADTRRIPEAT CVRALRGVET
     LLCEAVLRPV PVRDVATLLD LG
//