ID A0A109UKZ7_9GAMM Unreviewed; 1058 AA.
AC A0A109UKZ7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN Name=purL_1 {ECO:0000313|EMBL:AMC99691.1};
GN ORFNames=LOKO_00603 {ECO:0000313|EMBL:AMC99691.1};
OS Halomonas chromatireducens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=507626 {ECO:0000313|EMBL:AMC99691.1, ECO:0000313|Proteomes:UP000063387};
RN [1] {ECO:0000313|EMBL:AMC99691.1, ECO:0000313|Proteomes:UP000063387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGD 8-3 {ECO:0000313|EMBL:AMC99691.1,
RC ECO:0000313|Proteomes:UP000063387};
RX PubMed=26988058;
RA Sharko F.S., Shapovalova A.A., Tsygankova S.V., Komova A.V.,
RA Boulygina E.S., Teslyuk A.B., Gotovtsev P.M., Namsaraev Z.B.,
RA Khijniak T.V., Nedoluzhko A.V., Vasilov R.G.;
RT "Draft Genome Sequence of 'Halomonas chromatireducens' Strain AGD 8-3, a
RT Haloalkaliphilic Chromate- and Selenite-Reducing Gammaproteobacterium.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|EMBL:AMC99691.1, ECO:0000313|Proteomes:UP000063387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGD 8-3 {ECO:0000313|EMBL:AMC99691.1,
RC ECO:0000313|Proteomes:UP000063387};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
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DR EMBL; CP014226; AMC99691.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A109UKZ7; -.
DR STRING; 507626.LOKO_00603; -.
DR KEGG; hco:LOKO_00603; -.
DR PATRIC; fig|507626.3.peg.598; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000063387; Chromosome.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000313|EMBL:AMC99691.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000063387}.
FT DOMAIN 187..345
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 595..721
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 898
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1025
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1058 AA; 113665 MW; 50EA5DBDBAB7D4B3 CRC64;
MNPSLGATDS IPGIGPPLRP VSGAPHVFAA ATVLHGCGLV RAVQPHLPEI DLQSRGIAEY
LRQLLEARRG DVGQSRIEPL QLGTHGALEL FAFVHGDPGV IGVGLAADGV RSAIQPVGDL
AVADQAGRQG HVQVEQVAAI AGYFRTFEQD AMGAGGIERR GYHKPIMIAG SYGSIRDGHV
QKGVIPVGGK LIVMGGPAML IGLGGGAASS MASGTSSADL DFASVQRENP EIERRAQEVI
DRCWALGEAN PIRFFHDVGA GGLSNALPEL VKDGNRGGRF DLRAVPNAEP GMSPLEIWCN
EAQERYVLAV APEDLETFDA LCARERCPYA VVGEAIEAHH LEVRDGHFES QPVDLPMSVL
FGKPPKMQRE FERESRDLSG VMLDNLDLRE AMERVLRLPT VASKGFLITI GDRSITGMVA
RDQMVGPWQV PVADVAVTTA SYDTHAGEAM AMGERPPVAL IDPAASARLA VAEAITNLAA
APIAKLGDIK LSANWMSAAD HVGENQALYD AVHAVGMELC PALGIAIPVG KDSMSMRTAW
TTQDTKGEPE ERSVTSPLSL VVTGFAPVTD AMATLTPQIN LEQDESDLIL IDLGAGKNRL
GGSALAQVYG QVGDACPDLD DPEDLKAFFA VIQGLNRDGK LLAYHDRSDG GLLVTLLEMA
FAAHAGLEIK LDWLIDEPAD AVDALFAEEL GAVIQVNRQY TEEVLAQFAG AGIETCGVIA
RPRYDDQVRV TLFEEPLLET TRLLAQRTWA ETSYRMQALR DNPECAKSEF DGLLDSRDPG
LSASPAFDVD EDIAAPYVNT ARPAVAVLRE QGVNGQLEMA WAFDRAGFEA VDVHMSDILE
GRVGLESFKG LVACGGFSYG DVLGAGGGWA KSVLFNERAR EQFAAFFARD DSFGLGVCNG
CQMFAQLREL IPGTEDWPRF VRNESEQFEA RVAMVQVEKS PSILLAGMEG SRLPIAVAHG
EGRAEFRDSA HLRSMQVGTQ VALRYVDNYG QVTSHYPANP NGSPSGITGL TTPDGRVTIM
MPHPERVVRA VTNSWRPAEW SQEGAWMRLF RNARVWLD
//
