ID   A0A109UX70_9SACH        Unreviewed;       865 AA.
AC   A0A109UX70;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=AW171_hschr42803 {ECO:0000313|EMBL:AMD20882.1};
OS   Eremothecium sinecaudum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=45286 {ECO:0000313|EMBL:AMD20882.1, ECO:0000313|Proteomes:UP000243052};
RN   [1] {ECO:0000313|EMBL:AMD20882.1, ECO:0000313|Proteomes:UP000243052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58844 {ECO:0000313|EMBL:AMD20882.1,
RC   ECO:0000313|Proteomes:UP000243052};
RA   Dietrich F.S.;
RT   "Genome sequence of the yeast Holleya sinecauda.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CP014244; AMD20882.1; -; Genomic_DNA.
DR   RefSeq; XP_017987878.1; XM_018132389.1.
DR   AlphaFoldDB; A0A109UX70; -.
DR   STRING; 45286.A0A109UX70; -.
DR   GeneID; 28724150; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000243052; Chromosome iv.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF59; V-TYPE PROTON ATPASE SUBUNIT A, GOLGI ISOFORM; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        449..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        494..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        571..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        601..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        664..683
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        768..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        797..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          118..152
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   865 AA;  99681 MW;  359F1D67A677B13C CRC64;
     MNKEEAFFRS ADMTYIELYI PLEIAREVVC VLGNLGCVML KDMNKDLNAF QRGYVTQIRK
     FDEVERMLKY METVVEKHKQ DTWTYTYRYL ERHGRDDREH STLEQLIGAM NTHSIDSVNE
     VSEEISQFEA RIRQLDDSLV QLKERLDSLL LQRRVMFEFN RFLQVHPDMS GRIPNQDGRS
     LSEGYELNDI GAEEAWDHLL FETNEAEAQM PREPQMLLDT YKPRFIVTGS INRNKVETLN
     KILWRLLRGN LIFQHLPIDD SLDNQADPKI DVDCFIVFAH GEVLISKIKR VIESLNGSIY
     PIVPSQSFNE INDKISDLKQ ICSTTEQTLH TELFLVSNEL QMWNAIIKRE KSIYATLNLF
     RQESQGLVAE GWVPSMELIE VQNSLREYGE SVGSANTAVL NVIYTSRAPP TYHRTNKFTE
     AFQSIVDAYG VATYKEVNPG LATIVTFPFM FAIMFGDIGH GFIMLLAALY LVLNENNLSA
     MRRGEIFDMV FSGRYVILLM SLFSIYTGLM YNDIFSKSIN LFHTGWRWPT GFEEGEPIEA
     TYVGTYPFGI DYIWHGAENG LLFTNSYKMK LSILMGYIHM SYSYIFSYVN YRYKNSRVDI
     IGNFIPGLIF MQSIFGYLSW AIIYKWTKDW IKDGKPAPGL LNMLINMFLS PGVADEKLYV
     GQSFLQVILL LVALVCVPWL LLYKPLMLKR QNDLSMQKGF QSFEDQRVHE ILLEAQENAG
     DEMIVSDYHH EESPIDDFNF GDVMIHQTIH TIEFCLNCIS HTASYLRLWA LSLAHAQLSS
     VLWSMTIAGA FTSDNSGSIF AVIKVVVLFA MWFVLTVCIL VLMEGTSAML HSLRLHWVEA
     MSKFFEGEGY PYEPFSFKVI DSNIE
//