ID   A0A109UXX8_9SACH        Unreviewed;       755 AA.
AC   A0A109UXX8;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE            EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE   AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN   ORFNames=AW171_hschr31412 {ECO:0000313|EMBL:AMD19573.1};
OS   Eremothecium sinecaudum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=45286 {ECO:0000313|EMBL:AMD19573.1, ECO:0000313|Proteomes:UP000243052};
RN   [1] {ECO:0000313|EMBL:AMD19573.1, ECO:0000313|Proteomes:UP000243052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58844 {ECO:0000313|EMBL:AMD19573.1,
RC   ECO:0000313|Proteomes:UP000243052};
RA   Dietrich F.S.;
RT   "Genome sequence of the yeast Holleya sinecauda.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP014243; AMD19573.1; -; Genomic_DNA.
DR   RefSeq; XP_017986569.1; XM_018131543.1.
DR   AlphaFoldDB; A0A109UXX8; -.
DR   STRING; 45286.A0A109UXX8; -.
DR   GeneID; 28722777; -.
DR   OrthoDB; 2140072at2759; -.
DR   Proteomes; UP000243052; Chromosome iii.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00672; CysRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR   InterPro; IPR015803; Cys-tRNA-ligase.
DR   InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00435; cysS; 1.
DR   PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF01406; tRNA-synt_1e; 1.
DR   PRINTS; PR00983; TRNASYNTHCYS.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          55..469
FT                   /note="tRNA synthetases class I catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01406"
FT   REGION          666..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  86221 MW;  F3E1DE2C721DC322 CRC64;
     MHLFLKRSVT RTIMSSSTSK IAQPKWIKPD AIKEQPALKL YNSLTRNKDE FVPISKSRKV
     TWYSCGPTVY DAAHMGHARN YVTIDINRRI LEDYFGYDVD FVQNVTDIDD KIIIRARQEH
     LFEKYVSECS KVDDACLKKV KEAILAYISS KVDSKIETIE SYNEWEKKID LGKVKVEDPK
     LAMHVAAVRK AVDALNGHDQ KPVREFLDAV KDVLVPVLDS EFGASITDPE VFRKLAAYWE
     RSFNEDMRRL NVRAPTVTTR VSEYVDEIIT FVKRIIDNGY AYVTDDGSVY FDTVRFDSAP
     NHDYAKCQPW NRGQHDLIAD GEGALSSSSG KRSANDFALW KASKAGEPQW ESPWGAGRPG
     WHIECSVMAS DVLGSTIDIH SGGIDLAFPH HDNELAQSEA CFENSQWVNY FLHTGHLHIE
     GQKMSKSLKN FITIEEALEK YSVRQMRLAF AFTQWNNQLD FKESAMAEVR AWEQSVGNYF
     RTVRALIHES MEKDVTTRQS APEAQLRREL AEVVERGHVQ LCDNLSVGLV LRGVADIVGK
     ANVYIAERGK DVRIEVLSEI ARYATKMISL IGIEVRSDGL GWKEAEKSTG EGFEEDVLPY
     VRCLSHFRDE IRQLARNNAS SKEILRLADV LRDEHLVKLN VILEDRQEGP ALVKFIDENE
     RKRLVEEQAE RTKREQQRKA AAEEARKRDA ARREKARVPA EVMFLQSAEY SAWDENGVPV
     SDASGEPLSK SMKKKLLKQW QQQKKLNEEF KEEST
//