ID A0A117E3S0_ASPNG Unreviewed; 154 AA.
AC A0A117E3S0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Multiprotein-bridging factor 1 {ECO:0000256|ARBA:ARBA00014317};
GN ORFNames=ABL_10173 {ECO:0000313|EMBL:GAQ47512.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ47512.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- FUNCTION: Transcriptional coactivator that stimulates GCN4-dependent
CC transcriptional activity by bridging the DNA-binding region of GCN4 and
CC TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved
CC in induction of the ribosome quality control (RQC) pathway; a pathway
CC that degrades nascent peptide chains during problematic translation.
CC Required to prevent stalled ribosomes from frameshifting.
CC {ECO:0000256|ARBA:ARBA00035107}.
CC -!- SIMILARITY: Belongs to the MBF1 family.
CC {ECO:0000256|ARBA:ARBA00009802}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ47512.1}.
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DR EMBL; BCMY01000030; GAQ47512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A117E3S0; -.
DR PaxDb; 5061-CADANGAP00002689; -.
DR VEuPathDB; FungiDB:An02g12390; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1145066; -.
DR VEuPathDB; FungiDB:ATCC64974_52880; -.
DR VEuPathDB; FungiDB:M747DRAFT_293670; -.
DR OMA; NKAHQGT; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR PANTHER; PTHR10245:SF15; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1; 1.
DR PANTHER; PTHR10245; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 87..143
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 154 AA; 16772 MW; CA46A04F96F1F218 CRC64;
MSDWDSVTRI GARHTGGPAT RETVVKGKSA LNAAQRQGLV IGTEKKYATG NSAGRSGAPE
GQHLTKVDRS DDIVKPKTVG YQVADAIKKR RNEEGYKMTQ KELATKCNTT ITVVQDFERG
TATPDQKVLS AMERVLNVKL RGTGIGQEKF PKKK
//
