ID A0A117IUW2_9ACTN Unreviewed; 406 AA.
AC A0A117IUW2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KUH35692.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:KUH35692.1};
GN ORFNames=ATE80_27715 {ECO:0000313|EMBL:KUH35692.1};
OS Streptomyces kanasensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=936756 {ECO:0000313|EMBL:KUH35692.1, ECO:0000313|Proteomes:UP000054011};
RN [1] {ECO:0000313|EMBL:KUH35692.1, ECO:0000313|Proteomes:UP000054011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZX01 {ECO:0000313|EMBL:KUH35692.1,
RC ECO:0000313|Proteomes:UP000054011};
RA Zhang G., Han L., Feng J., Zhang X.;
RT "Genome-wide analysis reveals the secondary metabolome in Streptomyces
RT kanasensis ZX01.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUH35692.1}.
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DR EMBL; LNSV01000118; KUH35692.1; -; Genomic_DNA.
DR RefSeq; WP_058945013.1; NZ_LNSV01000118.1.
DR AlphaFoldDB; A0A117IUW2; -.
DR STRING; 936756.ATE80_27715; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000054011; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853:SF21; 3-KETOACYL-COA THIOLASE; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KUH35692.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054011};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 5..274
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 43009 MW; B8C8E28E28C0B995 CRC64;
MPEAVIVSAA RSPIGRAFKG SLKDLRPDDL TATIIQAALA KVPELDPRDI DDLMLGCGLP
GGEQGYNLGR IVAVRMGMDH LPGCTLTRYC ASSLQTTRMA LHAIKAGEGD VFISAGVETV
SRYVKGNSDS LPDTHNPVFD EAQARTASRA EHGGDEWHDP REDGLVPDAY IAMGQTAENL
ALLKGVSRQE MDEFGVRSQN LAEQAIKNGF WEREITPVTL PDGTVVSTDD GPRAGVTLEG
VQGLKPVFRP DGRVTAANCC PLNDGAAALV VMSDTKAREL GLTPLARVVS TGVSGLSPEI
MGYGPVEASR RALKHAGLTI DDIDLVEINE AFAAQVIPSY RDLGIPLEKL NVNGGAIAVG
HPFGMTGARI TGTLINSLQF HDKQFGLETM CVGGGQGMAM VIERLS
//