ID A0A117JK24_9MYCO Unreviewed; 421 AA.
AC A0A117JK24;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Mycofactocin radical SAM maturase {ECO:0000313|EMBL:KUI16758.1};
GN ORFNames=AU193_21375 {ECO:0000313|EMBL:KUI16758.1};
OS Mycobacterium sp. GA-1285.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1772282 {ECO:0000313|EMBL:KUI16758.1, ECO:0000313|Proteomes:UP000053702};
RN [1] {ECO:0000313|EMBL:KUI16758.1, ECO:0000313|Proteomes:UP000053702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GA-1285 {ECO:0000313|EMBL:KUI16758.1,
RC ECO:0000313|Proteomes:UP000053702};
RG TB Trials Study Group;
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E.L., Macaden R.,
RA Grewal H.M.S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUI16758.1}.
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DR EMBL; LQIS01000023; KUI16758.1; -; Genomic_DNA.
DR RefSeq; WP_064422944.1; NZ_LQIS01000023.1.
DR AlphaFoldDB; A0A117JK24; -.
DR STRING; 1772282.AU193_21375; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000053702; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR023913; MftC.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR03962; mycofact_rSAM; 1.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR SFLD; SFLDF00316; C-terminal_tyrosine_decarboxyl; 1.
DR SFLD; SFLDG01216; thioether_bond_formation_requi; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 20..230
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 360..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 45044 MW; 63A3E3C161BEE7DC CRC64;
MTSTETVRVP RLVEQFEHGL DAPICLTWEL TYACNLACVH CLSSSGKRDP RELTTQQCKD
VIDELERMQV FYVNIGGGEP TVRSDFWELV DYATAHHVGV KFSTNGVRIT PEVAARLASS
DYVDVQISLD GATAEINDAV RGAGSFAMAT RALQNLADAG FKDAKISVVV TRHNVDQLDE
FAALAAQYGA TLRITRLRPS GRGADVWDDL HPTADQQVRL YNWLVAKGER VLTGDSFFHL
AGLGEPGALA GLNLCGAGRV VCLIDPVGDV YACPFAIHDR FHAGNILSDG GFQNVWKNAP
LFRELREPQS AGACGSCGHY DSCRGGCMAA KFFTGLPLDG PDPECVEGYG APALARERVK
PKSSVDHSRS GPVMLKLLTT PPRSKVGAGS PPRSDVGAGA PPRSKVGAGA PPKRLCNESP
V
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