ID A0A117ML10_9ACTN Unreviewed; 1113 AA.
AC A0A117ML10;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|SMART:SM00255};
GN ORFNames=ADL15_47140 {ECO:0000313|EMBL:KUL22991.1};
OS Actinoplanes awajinensis subsp. mycoplanecinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL22991.1, ECO:0000313|Proteomes:UP000053244};
RN [1] {ECO:0000313|EMBL:KUL22991.1, ECO:0000313|Proteomes:UP000053244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL22991.1,
RC ECO:0000313|Proteomes:UP000053244};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL22991.1}.
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DR EMBL; LLZH01000335; KUL22991.1; -; Genomic_DNA.
DR RefSeq; WP_067706793.1; NZ_LLZH01000335.1.
DR AlphaFoldDB; A0A117ML10; -.
DR OrthoDB; 134501at2; -.
DR Proteomes; UP000053244; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00255; TIR; 1.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053244};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 188..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..146
FT /note="TIR"
FT /evidence="ECO:0000259|SMART:SM00255"
FT REPEAT 543..569
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 855..896
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 955..987
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 991..1024
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 228..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 118882 MW; 544A6A179111E14A CRC64;
MPFDGFISYS HAADGRLAPA VQRGLHRLAR PWHRRRALWI FRDQTGLAVT PKLWSSIQEA
LDGSNHFVLL ASPEAARSPW VNREIEHWLA TKSADQILPV VTDGDWFWDA GAGDFTAGST
AVPAALRGVF TEEPLFLDLR WARDDLHLSL QHVRFRDAIA QLAAPMHGVS KDELEGEDVR
QHRRVRRLGV VAVSMLVLLT LVTSLTGMVA VRNADRANAA VVEADRQEQV ATQQRTTAER
ATEESQRQQE NARVQEARAQ TAKEETGRQT LLAGEQQALA EEAAAEAERE QDAAERYRAT
AARQKANAER QQKLARGAGE EAQRQRAEAD REKASAQRQQ ELADQASARA TEQKKLAAKY
HAQARKAEEE RKRQEKLARE AADEARRQRE AAAKQQRAEI SRRLMVRARA MIVDDPKKAL
MLGVAAQRLN PEPQTLEQLS HLVMSTHYAG ALTGVTTVVP VTGQVVATAD TGGTVSLWDG
TDPAEPVRLA TVPAGATADT TLATAPDGHT LAVVNGGAEV ALWNVTDPAH PARRAPITDA
AGITTVTFSP DGHTAAASTR DKNTVLWDLT GTAPAPLATL PAAYPLQFGP DGRTAVTSGA
VVRVWDLTDP AHPVPGAELA VAFGNPITDA AIAFSPKVPV VAVEQDGDYV GLWDLSEPAT
PHPGLSKLAA TGDAHLSAMA FGPDGLTLAL ADSDGRTALW TIGDDDAFPW FSTQLATLNT
ADGAVGSLAF SADGRTLTTV GTARRTATLW STKGRFAKEP VATLPWPLPG RVVGLEFGPD
NRSLLAAGRQ GPAVPWDLTD PAAPVQGATV PLLGSTVDGI TLSPDGRTLA VTGVNKTVTL
LDMTRPDAPA LLSTLDDGGD LVYTVTFSPD SRTLAVGRRD GKTTLWDVTD REKPVSRTVL
ALRKTLTTIA FAPDGRTMAA GEGYNVSLWD VTNLAAPARL TSIPLKDWIS FTANTLVFSP
DGRTLAAGAD DATVLLWDVA DPAQPRQVAA LTGHTNAVLW VAFTPDGRSL ASASIDDTIM
LWDIAEMSDP VPYATIKTPD LQSYNVALSR DGRTIAAGGT FGAPSKNVTL WDVRVPADLA
ADPAGNACLV SGRGLTADEW KSYVPELPHQ STC
//
