ID A0A117NZ21_9ACTN Unreviewed; 389 AA.
AC A0A117NZ21;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KUM70075.1};
GN ORFNames=AQI70_31070 {ECO:0000313|EMBL:KUM70075.1};
OS Streptomyces curacoi.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146536 {ECO:0000313|EMBL:KUM70075.1, ECO:0000313|Proteomes:UP000054024};
RN [1] {ECO:0000313|EMBL:KUM70075.1, ECO:0000313|Proteomes:UP000054024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40107 {ECO:0000313|EMBL:KUM70075.1,
RC ECO:0000313|Proteomes:UP000054024};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces curacoi DSM 40107, type strain for
RT the species Streptomyces curacoi.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM70075.1}.
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DR EMBL; LMWJ01000025; KUM70075.1; -; Genomic_DNA.
DR RefSeq; WP_062155786.1; NZ_KQ947993.1.
DR AlphaFoldDB; A0A117NZ21; -.
DR STRING; 146536.AQI70_31070; -.
DR OrthoDB; 3761315at2; -.
DR Proteomes; UP000054024; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000054024};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KUM70075.1}.
FT DOMAIN 5..258
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..387
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 345
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 375
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 389 AA; 41233 MW; 625B0A67D0D38940 CRC64;
MRDAVIVEAV RTPMGKGKPN GSLAHVHPVE LLAHTLRTLV ERSGVDPALI DDVIGGTVDQ
VGEQAMNTTR YAALSAGFPE SVPATTVDRQ CGSSQQAVHF AAQGVISGAY DLVVACGVES
MSRVPMWSNV PPGKDPFGPG IAERYPEGLV PQGISAELIA AKWSITREQM DAFAVSSHRK
AAEAWEKGLF DAEVAPLDVV ARDECVRPSS TPEILAGLKP AYYDPAFAER FPQIEWNVTA
GNASPVNDGA SAVLITSSET AARLGLRPLA RLHSFAVTGS DPLLMLTGVV PATEKVLRRA
GLRLDDIDLF EVNEAFSSVV LAWRQETGAD LAKVNVHGGA IAIGHPLGAS GTRLTTTLVH
AMRERRARYA LQTMCEAGGL ANAMILETV
//
