ID A0A117PLE6_9ACTN Unreviewed; 412 AA.
AC A0A117PLE6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Precorrin-6Y C5,15-methyltransferase {ECO:0000313|EMBL:KUM81817.1};
GN ORFNames=AQI70_00375 {ECO:0000313|EMBL:KUM81817.1};
OS Streptomyces curacoi.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146536 {ECO:0000313|EMBL:KUM81817.1, ECO:0000313|Proteomes:UP000054024};
RN [1] {ECO:0000313|EMBL:KUM81817.1, ECO:0000313|Proteomes:UP000054024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40107 {ECO:0000313|EMBL:KUM81817.1,
RC ECO:0000313|Proteomes:UP000054024};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces curacoi DSM 40107, type strain for
RT the species Streptomyces curacoi.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM81817.1}.
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DR EMBL; LMWJ01000001; KUM81817.1; -; Genomic_DNA.
DR RefSeq; WP_062142409.1; NZ_KQ947984.1.
DR AlphaFoldDB; A0A117PLE6; -.
DR STRING; 146536.AQI70_00375; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000054024; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KUM81817.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KUM81817.1}.
FT DOMAIN 1..183
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 255..324
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
SQ SEQUENCE 412 AA; 42291 MW; 7BA7060731A4B0B6 CRC64;
MITVVGTGTG APPPEDVLAD AELVVGGRRH LGAVRLPDGV ERVVLGALAP ALDTIEEYVA
KDRPVLVLAS GDPGFFGVVR ALAERFGPER LEVRPGVSSV ATAFARLGLT WDDAVVVSAH
GRAPRAAVNV CRAHPKVAVL TGPGAGPAEL GAALRDSGRV LVVASALGDP ERERVERVTP
AEAAARDWGT AVSVVLCLDE TRMLGPARTL AGPEARPAGW ALAEDAFAHR DSMITKFEVR
ALALARLGPR LGDLVWDVGA GSGSVAVECA RLGAAAVAVE KAPDGVERVR ANAAAHGVDV
RVVHGAAPEA LAKLADDPDA VFVGGGGREL PAVVTACARR ARRTVVVAMA ALDRVPAARE
ALTNAGFSCD GVLLQSSRLA PLPGDVTRLA ATNPVFLLWG VRPQACSEGV AL
//
