ID A0A117R2N8_9ACTN Unreviewed; 684 AA.
AC A0A117R2N8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=AQJ54_14540 {ECO:0000313|EMBL:KUN67754.1};
OS Streptomyces griseorubiginosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN67754.1, ECO:0000313|Proteomes:UP000054375};
RN [1] {ECO:0000313|EMBL:KUN67754.1, ECO:0000313|Proteomes:UP000054375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN67754.1,
RC ECO:0000313|Proteomes:UP000054375};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT strain for the species Streptomyces griseorubiginosus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN67754.1}.
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DR EMBL; LMWV01000008; KUN67754.1; -; Genomic_DNA.
DR RefSeq; WP_062237624.1; NZ_KQ948736.1.
DR AlphaFoldDB; A0A117R2N8; -.
DR Proteomes; UP000054375; Unassembled WGS sequence.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR CDD; cd16014; PLC; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017767; Bact_PC-PLC.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03396; PC_PLC; 1.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000054375};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 497..583
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 599..668
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT REGION 460..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 75000 MW; D8D5EAE6A589B2BF CRC64;
MADVNRRRFL QLAGATTAFS ALSNSIQRAA ALPAHHRTGT IEDVEHVVVL MQENRSFDHY
FGSLRGVRGF GDPRPVTLDS SKSVWHQTDR NGKEILPFRP EANDLGMQFI QDLPHGWNDG
HAAFNGGKYD KWVPNKGSTT MAYLTREDIP FHYALADSFT ICDAYHCSFI GSTDPNRYYM
WTGYTGNDGQ GGGPVLGNDE AGYGWTTYPE RLEKAGVSWK IYQDVGDGLD ANGSWGWIPD
AYRGNYGDNS LLYFNQYRNA KPGDPLYDKA RTGTDYTKGE GYFDQLKADV KAGKLPQVSW
IVAPEAFTEH PNWPANYGAW YVAQVLDALT SDPKVWAKTA VFITYDENDG FFDHVVPAYP
AGSAAQGKST VDPALDLFQG SASHPAGPYG LGQRVPMLVV SPWSKGGYVC SETLDHTSII
RFLERRFGVH EPNISPWRRA VCGDLTAAFD FSRKDTKPVA LPDTDGFEPP DRERHPDYVP
VPPAVGALPR QERGLRPARP LKYAPHVDGS VDAKGGRFTL AFASGAKAGA AFLVTSGNRT
DGPWSYTTEA GKSVSDTWNS AYSKGSYDLT VHGPNGFLRS FKGSNKTAGP EVTARHSGDD
IELTFTNSGS GLVRLKVESG YGDRVRTFTV RPGTTVRHTF GLARSRRWYD LTVTADADPA
FLRRFAGHVE NGRPGVSDPA VITG
//
