ID A0A117RRT5_9ACTN Unreviewed; 683 AA.
AC A0A117RRT5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=AQJ67_02765 {ECO:0000313|EMBL:KUO05766.1};
OS Streptomyces caeruleatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=661399 {ECO:0000313|EMBL:KUO05766.1, ECO:0000313|Proteomes:UP000053429};
RN [1] {ECO:0000313|EMBL:KUO05766.1, ECO:0000313|Proteomes:UP000053429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUO05766.1,
RC ECO:0000313|Proteomes:UP000053429};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT strain for the species Streptomyces caeruleatus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO05766.1}.
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DR EMBL; LMWY01000003; KUO05766.1; -; Genomic_DNA.
DR RefSeq; WP_062716330.1; NZ_KQ948924.1.
DR AlphaFoldDB; A0A117RRT5; -.
DR STRING; 661399.AQJ67_02765; -.
DR OrthoDB; 4181857at2; -.
DR Proteomes; UP000053429; Unassembled WGS sequence.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR CDD; cd16014; PLC; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017767; Bact_PC-PLC.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03396; PC_PLC; 1.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000053429};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 496..582
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 598..667
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT REGION 452..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75054 MW; 6476C10E9457F74E CRC64;
MPEVNRRRFL QLAGTTTAFT ALSSSIQRAA AIPANHRTGS IEDVEHIVVL MQENRSFDHY
FGKLRGVRGF GDPRPVKRDD GKSIWHQSNG GKDILPFHPD AGDLGMQFLE GLPHGWTDGQ
QAYNGGKYDK WVPAKGTTTM AYLTREDIPF HYALADAFTV CDAYHCSFIG STDPNRYYMW
TGCTGNDGTG GGPVLGNDEL GYGWTTYPER LEQAGVSWKI YQDIGDGLDA KGSWGWIQDA
YRGNYGDNSL LYFNKYRDAK PGDPWYDKAR TGTDAKSGEG YFDRLKADVK AGKLPQISWI
AAPEAFSEHS NWPSNYGAWY IAQVLDALTS NPEVWSKTAL FITYDENDGF FDHVVPPLPP
KDASRGKSTV DVSLDLYKGD SNRPAGPYGL GPRVPMLVVS PWSKGGYVCS ETLDHTSILR
FMERRFGVRE TNISPWRRAV CGDLTSAFDF SRKDSRPAAL PGTDEYEPQD RERHPDYKPT
PPADPDMPRQ ERGLRPTRPL RYAPHVDGSV DAAAGKFTLA FASGAKAGAA FHVTSGNRTD
GPWTYTTEAG KSIADTWNSA YSNGSYDLTV HGPGGFVRWF KGSNKTAGPE VTARHTGDDV
ELTLTNRGTA SVRLKIANGY GGRATTVTVR PGATVCRTVD LAGSRRWYDL TVAADADPAF
LRRFAGHVEN GRPGVSDPAI ITE
//
