ID A0A117RW90_9ACTN Unreviewed; 728 AA.
AC A0A117RW90;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Kinase {ECO:0000313|EMBL:KUO12529.1};
GN ORFNames=AQJ58_10030 {ECO:0000313|EMBL:KUO12529.1};
OS Streptomyces sp. DSM 15324.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1739111 {ECO:0000313|EMBL:KUO12529.1, ECO:0000313|Proteomes:UP000053431};
RN [1] {ECO:0000313|EMBL:KUO12529.1, ECO:0000313|Proteomes:UP000053431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15324 {ECO:0000313|EMBL:KUO12529.1,
RC ECO:0000313|Proteomes:UP000053431};
RA Ruckert C., Winkler A., Kalinowski J., Wink J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. DSM 15324, isolated from soil.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO12529.1}.
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DR EMBL; LMXA01000007; KUO12529.1; -; Genomic_DNA.
DR RefSeq; WP_067247509.1; NZ_KQ949024.1.
DR AlphaFoldDB; A0A117RW90; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000053431; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUO12529.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000053431};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUO12529.1}.
FT DOMAIN 91..188
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 455..516
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 649..723
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 79139 MW; 203F17F9309AA0EA CRC64;
MSAEATNPAM PGPVAPATSR RRSLPRIDLR RLGRAALLGS PARGRLPDAI GHVVEAHRAH
HPDADLEPLR RAYVLAESSH RGQMRKSGEP YITHPLAVTL ILAELGAETT TLTASLLHDT
VEDTDVTLDQ VREQFGEEVR YLVDGVTKLE KVDYGAAAEP ETFRKMLVAT GSDVRVMSIK
LADRLHNMRT LGVMRPEKQE RIAKITRDFL IPLAERLGVQ ALKTELEDLV FAILHPEEYE
HTRELIVDNA SRADDPLAEF ADAMRAVLRE AGIQAEVLIR PRHFVSVHRV SRKRGELRGC
DFGRLLVLVG EDADCYAVLG ELHTCMTPVV SEFKDFIAVP KFNLYQSLHT AVARGDGQVA
EVLIRTHQMH KVAEAGVVAL GNPYAGPQDE QTREGAPADA DRPGGERPGG GERPDGERVD
PTRPGWLSRL LAWQEAAPDT DTFWSTLRED LAQDREITVF RPDGGTLGLP DGATCVDAAY
AQYGEDAHAC IGARVNGRLA TLSTVLRDGD TVQLLMGQDP ASEPSREWLE HAHTPAARIA
IQRWLATHPA PAEPEESVDA ARTVTDIPAA DAPLSRPDTA ITVVGRPDAG VRLAGCCTPV
PADEVTGFAV RGGVVTVHRV ECAAVARMTD AGRPAVDVSW GDTTECRVTL IAESFGRPHL
LADLTEAMAM EGAEIVSATV EPPSQQRVRH TYTLQLPDAA HLPTLMRAMR NVPGVYDVAR
AQHHDSAS
//
