ID A0A120A2Q3_BACSE Unreviewed; 773 AA.
AC A0A120A2Q3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=DUF4962 domain-containing protein {ECO:0000313|EMBL:RHF78468.1};
DE SubName: Full=Heparin and heparin-sulfate lyase {ECO:0000313|EMBL:KWR55633.1};
DE EC=4.2.2.7 {ECO:0000313|EMBL:KWR55633.1};
DE Flags: Precursor;
GN Name=hepB_1 {ECO:0000313|EMBL:KWR55633.1};
GN ORFNames=AA415_01413 {ECO:0000313|EMBL:KWR55633.1}, DW668_00160
GN {ECO:0000313|EMBL:RHF78468.1}, DWZ78_16315
GN {ECO:0000313|EMBL:RHM15524.1};
OS Bacteroides stercoris.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=46506 {ECO:0000313|EMBL:KWR55633.1, ECO:0000313|Proteomes:UP000056419};
RN [1] {ECO:0000313|EMBL:KWR55633.1, ECO:0000313|Proteomes:UP000056419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL09T03C01 {ECO:0000313|EMBL:KWR55633.1,
RC ECO:0000313|Proteomes:UP000056419};
RX PubMed=26768901; DOI=10.1186/s12864-016-2377-z;
RA Coyne M.J., Roelofs K.G., Comstock L.E.;
RT "Type VI secretion systems of human gut Bacteroidales segregate into three
RT genetic architectures, two of which are contained on mobile genetic
RT elements.";
RL BMC Genomics 17:58-58(2016).
RN [2] {ECO:0000313|EMBL:KWR55633.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL09T03C01 {ECO:0000313|EMBL:KWR55633.1};
RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA SanMiguel P., Csonka L.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000283762, ECO:0000313|Proteomes:UP000284604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF35-20 {ECO:0000313|EMBL:RHM15524.1,
RC ECO:0000313|Proteomes:UP000284604}, and AM25-16
RC {ECO:0000313|EMBL:RHF78468.1, ECO:0000313|Proteomes:UP000283762};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWR55633.1}.
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DR EMBL; LRGC01000005; KWR55633.1; -; Genomic_DNA.
DR EMBL; QRHJ01000001; RHF78468.1; -; Genomic_DNA.
DR EMBL; QRPN01000031; RHM15524.1; -; Genomic_DNA.
DR RefSeq; WP_060385679.1; NZ_QSSP01000035.1.
DR AlphaFoldDB; A0A120A2Q3; -.
DR SMR; A0A120A2Q3; -.
DR STRING; 46506.AA415_01413; -.
DR PATRIC; fig|46506.5.peg.1507; -.
DR Proteomes; UP000056419; Unassembled WGS sequence.
DR Proteomes; UP000283762; Unassembled WGS sequence.
DR Proteomes; UP000284604; Unassembled WGS sequence.
DR GO; GO:0047488; F:heparin lyase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.40.2750; -; 1.
DR Gene3D; 2.70.98.70; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR012480; Hepar_II_III.
DR InterPro; IPR040925; HepII_C.
DR InterPro; IPR032518; HepII_N.
DR Pfam; PF16332; DUF4962; 1.
DR Pfam; PF07940; Hepar_II_III; 1.
DR Pfam; PF18675; HepII_C; 1.
DR SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:KWR55633.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000056419};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..773
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036004324"
FT DOMAIN 93..262
FT /note="Heparinase II N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16332"
FT DOMAIN 687..773
FT /note="Heparinase II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18675"
SQ SEQUENCE 773 AA; 87872 MW; E574DB8D6F9A30B3 CRC64;
MKKSILFITS FFLCVFCLKS NAQQSRPEVT WENMEGVTVP IPPQVHPRLY VRSADLPDLK
KRMEHPHVKE VLATLNKLGK DRTPEEEAKV KDRGFRYYFE MRGVTSRVQV QALDYLVYGD
KKQARSAITA MLDTLQNVNY GTKGDLSRAS GVMLTCGAMV YDWCYDQMKE SEKKAYIESF
IRIAKTMECG YPPRNNEPIA GHSSEWMILR DMLSAGIAIY DEYPDMYNHV IKMMFKDYLP
VRNYIYSGHN YHQGTSYVNV RFSNDLFSLW ILQRMGAGAI YNPAQQFVLY DFLYRRRPDG
QVMPAGDTNP IRKNMPSYSL PAMLASSFYK DSYLAYEYER KPNIERHCLI FDILWRDLDL
KAKAPDDLPL TRYSGSPFGW MIARTAWDEN SVIAEMKINE QFVGNHQHLD GGSFQLYYKG
PLAIDAGAYQ GSSGGYNSPH NKNFFKRTIA HNSLLVYNPD EKFACWNYGG GGKTEFATND
GGQRMPGDRW ETCRSFEQLL SKDYTTGKAL AHGFGPDACK PDYSYLKGDI TQAYTDKVKE
AKRSFVFLNL HAAEVPAALI VFDKVVSSDP TFKKFWLLHS IEEPTIEGNR FIVRRTKNGD
TGMLQNHVLL PEAGNAQIEK VGGKGKEFWV FGTNYPNDAL PNRPDDANER GAWRVEVSPA
APATEDCFLN VMQVADNTCK RMHDVKRIDA EKVVGVQIAD RVVTFSRDSR PLSGKVDMKV
DGNAAMKFVI TDLIPGTWQI KKDGKVYIPA MEVRSDDGIL SFEGTAGHYE FLR
//
