ID A0A120I9E7_9LACT Unreviewed; 1206 AA.
AC A0A120I9E7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=AWM72_08020 {ECO:0000313|EMBL:AMB94704.1}, CYJ28_01730
GN {ECO:0000313|EMBL:PKZ23295.1};
OS Aerococcus sanguinicola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Aerococcus.
OX NCBI_TaxID=119206 {ECO:0000313|EMBL:AMB94704.1, ECO:0000313|Proteomes:UP000069912};
RN [1] {ECO:0000313|EMBL:AMB94704.1, ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|EMBL:AMB94704.1,
RC ECO:0000313|Proteomes:UP000069912};
RX PubMed=27103727;
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Complete Genome Sequences of Aerococcus christensenii CCUG 28831T,
RT Aerococcus sanguinicola CCUG 43001T, Aerococcus urinae CCUG 36881T,
RT Aerococcus urinaeequi CCUG 28094T, Aerococcus urinaehominis CCUG 42038 BT,
RT and Aerococcus viridans CCUG 4311T.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|Proteomes:UP000069912};
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Six Aerococcus type strain genome sequencing and assembly using PacBio and
RT Illumina Hiseq.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PKZ23295.1, ECO:0000313|Proteomes:UP000234239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0139 {ECO:0000313|EMBL:PKZ23295.1,
RC ECO:0000313|Proteomes:UP000234239};
RA Thomas-White K., Wolfe A.J.;
RT "Phylogenetic diversity of female urinary microbiome.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP014160; AMB94704.1; -; Genomic_DNA.
DR EMBL; PKGY01000001; PKZ23295.1; -; Genomic_DNA.
DR RefSeq; WP_067976024.1; NZ_PKGY01000001.1.
DR AlphaFoldDB; A0A120I9E7; -.
DR GeneID; 69592494; -.
DR KEGG; asan:AWM72_08020; -.
DR OrthoDB; 9758506at2; -.
DR Proteomes; UP000069912; Chromosome.
DR Proteomes; UP000234239; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000069912}.
FT DOMAIN 296..621
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 1206 AA; 139600 MW; F16865C80C6F0107 CRC64;
MTLHFLRMTD TYSDKSAVYA DIVADLRNHP DRQIFYLVPD HMKFDMEVQV LEAIQGLAKA
EEVSDGASGM MRLQVMSFER LAWLLLKEDW PHDKQALSSV GTMMLLRKVL HDLFDELKLY
RGEFNKIGFL SELADLFHEL EMGNIDPDSL DEILAQEDPQ ASSLKARQVD KLKELAMIYR
AYEAEQGRFT LASHAVYQAL DDYIRSEDMS QVRVVIDGFY RFTARQLQVI EAFLLKVPKL
EVILTADRAY RQSGPAWDDL FTITGEAYHQ VYALAKSHGI PVADDKFAGP NTAYAPAFAG
LDEYLRQRNR QAQSNETEGA ADLGNHLEIW KCESPYVESE QVANKIYQLV ASGQYRYKDI
QILTRDVDKY RYQILPYLEQ NEIPYFIDNA ESMQRHPLSR FLDSLYRIWR YNWRYQDIFN
LLRSELLMPL AYLEAEDRQS GQKAFRRVVD QTENVVLKNG YEGRRFWQSD YEWSYLELDA
QGQKIAREAD QVIEEEANRL KNFLFNSLDP LFKTWESSLK TKEVLTTFYR TLEELGIPQQ
ILNWRDDLID TGDLELARHH EQAWQEFVQI LDEYVLLFAE EDFSVELFFD LIQVAFREAK
YSIVPPSLDS VSISGLDSQR SSAKPVTFVL GLTRQSLPRQ YENHSLFSDE DRDLISQGLT
DLQSLAASTQ QKTVNEAFIA YKAFLSAYNK LYISYPYNEL GEKTSNISPF LDQVRQAYGL
EEKLHSSQNL VLQTHEEVHL GNWRSQVHHL ASKLSLAKMR REQLPASYAS LYQQVKALRQ
THPEIKKVLA GLNYSNQVKN LPADLAQALY GQPLFTSVSQ LELFNKDPFS YYLVYGLRLR
ERERMQLDPI QTGNYYHGLL QAFFDRALKD QIAIEDLTAD RVYSMLKNLV AQALEDEANT
IFTTSARFSW MNHALNRTLY QVIQQIIRQQ RVTKPRIRAN ELSFGLAGNS QKDLPAYELS
LAEGQSVFLR GRIDRLDTWQ YEGIDYLQVV DYKSSKQSYQ FRHIYEGLSL QLFAYAQVAL
SADQGGEGAE VFGTFHQLVS DQVRPIKKEA DFQGTALATM PKNYQLTGYY LADPDLLQAI
DPTTDEKESS LSYPYKWNKN FVLKKDAYGL NRQEWAWLLD FVDDKIRQTA QAILEGEIAL
APLRQDKESL YIPSLQYPLN AIACFDPVDG GNRYRDWRLM ANDRQTFFQE IQQALEEKGA
LDDERS
//
