ID A0A124EC30_9ACTN Unreviewed; 206 AA.
AC A0A124EC30;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Precorrin-8X methylmutase {ECO:0000313|EMBL:KUH36336.1};
DE EC=5.4.99.61 {ECO:0000313|EMBL:KUH36336.1};
GN Name=cobH {ECO:0000313|EMBL:KUH36336.1};
GN ORFNames=ATE80_24140 {ECO:0000313|EMBL:KUH36336.1};
OS Streptomyces kanasensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=936756 {ECO:0000313|EMBL:KUH36336.1, ECO:0000313|Proteomes:UP000054011};
RN [1] {ECO:0000313|EMBL:KUH36336.1, ECO:0000313|Proteomes:UP000054011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZX01 {ECO:0000313|EMBL:KUH36336.1,
RC ECO:0000313|Proteomes:UP000054011};
RA Zhang G., Han L., Feng J., Zhang X.;
RT "Genome-wide analysis reveals the secondary metabolome in Streptomyces
RT kanasensis ZX01.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the CobH/CbiC family.
CC {ECO:0000256|ARBA:ARBA00009774}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUH36336.1}.
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DR EMBL; LNSV01000081; KUH36336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A124EC30; -.
DR STRING; 936756.ATE80_24140; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000054011; Unassembled WGS sequence.
DR GO; GO:0016993; F:precorrin-8X methylmutase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10230; Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase; 1.
DR InterPro; IPR003722; Cbl_synth_CobH/CbiC.
DR InterPro; IPR036588; CobH/CbiC_sf.
DR PANTHER; PTHR43588; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR PANTHER; PTHR43588:SF1; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR Pfam; PF02570; CbiC; 1.
DR SUPFAM; SSF63965; Precorrin-8X methylmutase CbiC/CobH; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KUH36336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054011}.
FT DOMAIN 10..203
FT /note="Cobalamin biosynthesis precorrin-8X methylmutase
FT CobH/CbiC"
FT /evidence="ECO:0000259|Pfam:PF02570"
SQ SEQUENCE 206 AA; 21494 MW; 84CE04B14314CF8D CRC64;
MFDYEKDGAE IYRQSFATIR AEADLAGLPA DVSQVAVRMI HACGMVDLVR DLAYTPEVVS
RARAALRAGA PILCDAQMVA SGVTRKRLPA ANDVVCTLSD PSVPDLAAKL GTTRSAAALE
LWRDRLDGAV VAIGNAPTAL FRLLEMIREG APRPAAVLGI PVGFIGAAES KDALAASDLD
HIVVRGRRGG SAMTAAAVNA IASEVE
//
