ID   A0A124F3U3_9ACTN        Unreviewed;       324 AA.
AC   A0A124F3U3;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=DNA polymerase {ECO:0000313|EMBL:KUJ58994.1};
GN   ORFNames=ADL25_01925 {ECO:0000313|EMBL:KUJ58994.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ58994.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC       untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC       forks, which arise in vivo from mismatched or misaligned primer ends.
CC       These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC       exonuclease (proofreading) activity. May be involved in translesional
CC       synthesis, in conjunction with the beta clamp from PolIII.
CC       {ECO:0000256|ARBA:ARBA00025589}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ58994.1}.
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DR   EMBL; LMWH01000001; KUJ58994.1; -; Genomic_DNA.
DR   RefSeq; WP_059125790.1; NZ_LMWH01000001.1.
DR   AlphaFoldDB; A0A124F3U3; -.
DR   OrthoDB; 4317601at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:UniProt.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR   PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT   DOMAIN          12..123
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
SQ   SEQUENCE   324 AA;  34589 MW;  0AC638B8B2F907DA CRC64;
     MTILCVRFQL APMYEAALPG LLGLLEEFTP VVEALPPDGA LADLRGAGRY FGRDTAELAT
     VIRVRALAHH GVDCAIGAGP GPMLARMALR EAAPGTIRLV PEGRTAAAEF LAGLPVGALP
     RVGAVTARTL CEYGLDTVGK VAGAPLSTVQ RLVGARAGRE LHEKANGVDR GRVVPNGVSR
     SLVAERPFTR DELDPDRHRR ALLSAAEELG SRLRNVGRVC GALTLTTRYA DRSSTTRSRT
     LAEPTAHSAA LTTEAYRLYE ALGLQRARVR ALVLRAEGLT PAEQASRQLT FDPVDDKVRR
     IEEVADRARA RFGPRAVMPG TLAA
//