ID A0A124H3B8_9ACTN Unreviewed; 857 AA.
AC A0A124H3B8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=AQI70_14210 {ECO:0000313|EMBL:KUM77086.1};
OS Streptomyces curacoi.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146536 {ECO:0000313|EMBL:KUM77086.1, ECO:0000313|Proteomes:UP000054024};
RN [1] {ECO:0000313|EMBL:KUM77086.1, ECO:0000313|Proteomes:UP000054024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40107 {ECO:0000313|EMBL:KUM77086.1,
RC ECO:0000313|Proteomes:UP000054024};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces curacoi DSM 40107, type strain for
RT the species Streptomyces curacoi.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM77086.1}.
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DR EMBL; LMWJ01000008; KUM77086.1; -; Genomic_DNA.
DR RefSeq; WP_062148681.1; NZ_KQ947987.1.
DR AlphaFoldDB; A0A124H3B8; -.
DR STRING; 146536.AQI70_14210; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000054024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUM77086.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 379..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 622..833
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 832..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 92076 MW; 8FCE71C7E6877460 CRC64;
MGRGKLRIYL GAAPGVGKTY AMLSEAHRRV ERGTDCVVAF VEHHGRPRTE VMLHGLEQIR
RKELEYRGAF FTEMDVDAVL ARRPQVALVD ELAHTNVPGS RNAKRWQDVA ELLAAGIDVI
STVNIQHLES LGDVVESITG VRQRETVPDE VVRRADQVEL VDMSPQALRR RMAHGNIYEP
DKVDAALSNY FRPGNLTALR ELALLWVADR VDEYLKQYRS DHRVSTIWGS RERIVVGLTG
GPEGRTLIRR AARLAEKGAG GEVLAVYIAR SDGLTSASPK ELAVQRTLVE DLGGTFHHVL
GDDIPAALLA FARGANATQI VLGSSRRKSW QYVFGPGVGA TVARDSGPDL DVHIVTHEEA
AKGRGLPVAR GARLGRSRIL WGWLTGVGGP LLLTLLLTHT AVDLGLANDM LLFLTLTVAA
ALLGGRYPAL ASAAVGSMLL NWYFTAPVHH ITIADPKNLL ALVIFVFVAV AVASVVDLAA
RRTHQAARLR AESEILSFLA GNVLRGETGL EELLERVRET FGMQSAALLE RESDLDPWTC
AGRVGTGHAP ARPEDADVDV PVGDHMALAL TGRVLPAEDR RVLAAFAAQS AVVLDRQRLQ
READQAKELA EGNRIRTALL AAVSHDLRTP LAGIKAAVSS LRSDDVAWSE EDEAELLEGI
EEGADRLDHL VGNLLDMSRL QTGTVTPLIR EIDLDEVVPM ALGGVPEGSV ELDVPESLPM
VAVDPGLLER SVANLVENAV KYGPGDSAVL VSASAIADRV EVRVVDRGRG VPDEAKERIF
EPFQRYGDAP RGAGVGLGLA VARGFAEAMG GTLNAEDTPG GGLTMVLTLR AAGPGPELQE
GAASTDRPVE PERQVTP
//