ID   A0A124H5U1_9ACTN        Unreviewed;       984 AA.
AC   A0A124H5U1;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Lantibiotic dehydratase {ECO:0000313|EMBL:KUM79696.1};
GN   ORFNames=AQI70_05650 {ECO:0000313|EMBL:KUM79696.1};
OS   Streptomyces curacoi.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=146536 {ECO:0000313|EMBL:KUM79696.1, ECO:0000313|Proteomes:UP000054024};
RN   [1] {ECO:0000313|EMBL:KUM79696.1, ECO:0000313|Proteomes:UP000054024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40107 {ECO:0000313|EMBL:KUM79696.1,
RC   ECO:0000313|Proteomes:UP000054024};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces curacoi DSM 40107, type strain for
RT   the species Streptomyces curacoi.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUM79696.1}.
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DR   EMBL; LMWJ01000004; KUM79696.1; -; Genomic_DNA.
DR   RefSeq; WP_062145165.1; NZ_KQ947985.1.
DR   AlphaFoldDB; A0A124H5U1; -.
DR   STRING; 146536.AQI70_05650; -.
DR   OrthoDB; 1273722at2; -.
DR   Proteomes; UP000054024; Unassembled WGS sequence.
DR   InterPro; IPR006827; Lant_deHydtase_N.
DR   InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR   NCBIfam; TIGR03891; thiopep_ocin; 1.
DR   Pfam; PF14028; Lant_dehydr_C; 1.
DR   Pfam; PF04738; Lant_dehydr_N; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054024}.
FT   DOMAIN          10..651
FT                   /note="Lantibiotic dehydratase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04738"
FT   DOMAIN          723..970
FT                   /note="Thiopeptide-type bacteriocin biosynthesis"
FT                   /evidence="ECO:0000259|Pfam:PF14028"
SQ   SEQUENCE   984 AA;  107511 MW;  BA257254548397E2 CRC64;
     MAWLRAVWAD TDVAEALQHS SPVLATQVGA LCTAEYPALR DVRRAVLSVA RYLLRTQHRA
     TPFGLFAGVA TAEFGPQARA DWGEEHVAVG RAGAEWLAAL VARLESCPDL LERLPVVINN
     TVTYRGDRLI VPFQPDVQDD RTRPVEASLA LTGPVHAVLA ATRLPIRFGT LVDKLQAEFP
     EAGPEKARQL LAELIRRRVL ITGLHAPSTE TDALGYLLGQ LDAIDAGTLA PVAETVRELR
     AVRAGLEECA THGGRDSVAA RMRDLVPGLR RHPVALDLRL DAQIVLPEAV AREIERSALI
     LTHLSIRPYG TAAWNAYHQR FYERYGIGTM VPLVEAVADS GTGYPDGYPG ASASARRPRV
     SARDDALVRL AQAAALDGRD EVILTDEQIE ALDAGPDEPR LPPHLEIGVR VHAASLEELQ
     RGRFRLEVVS VSRGVGVSTG RFLSVLAPAD REALVAELAG LPAADGNTVP AQLSFPPLLP
     ESAHVTRSPQ VLPTVISLQE HRAPQDTVLT PEDLAVGCDG RRMYLAVPER GHRVEAVGVH
     ALNLRTHTPP LVRFLTELSR AQCAQVTVFD WGAAAAMPFL PRLRYGRTVL APARWRLEVS
     ELPGHARPRA EWDAALSDWR ARRRLPRRVH LVEDDRRLFL DLDEAGHRAL LRRHLDHRRL
     AVLVEAPEPE AYGWCGGRAH EVVVPLKATR PSAWPPLPAP SRARALSAAQ MQTPAASSVV
     LAALYGAPRR QDVLLSQHLP GLLEQLGNPP WWFIRFRDPD QHLRVRIALP DPEAFADTAR
     TVSAWADELR SIGLLADLRY PTSYREMGRW GSGTAWEAAE EVFRADSRAI LVQLAQPQRP
     GLRTLVVAHT VAIASAFLGS TAAGMRWLID HIPPTAPAPV PRPQFTDAVR LADPSDDWAA
     LRQVPGGDAI VSGWADRDAA LAAYRPHLPG PDTQGIAVDD VLTSLLHVHF VRHVAVNFPE
     EEVCLYLARA AALAWTARTR GRAS
//