ID A0A124H796_9ACTN Unreviewed; 432 AA.
AC A0A124H796;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN ORFNames=AQI70_03095 {ECO:0000313|EMBL:KUM81196.1};
OS Streptomyces curacoi.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146536 {ECO:0000313|EMBL:KUM81196.1, ECO:0000313|Proteomes:UP000054024};
RN [1] {ECO:0000313|EMBL:KUM81196.1, ECO:0000313|Proteomes:UP000054024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40107 {ECO:0000313|EMBL:KUM81196.1,
RC ECO:0000313|Proteomes:UP000054024};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces curacoi DSM 40107, type strain for
RT the species Streptomyces curacoi.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM81196.1}.
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DR EMBL; LMWJ01000002; KUM81196.1; -; Genomic_DNA.
DR RefSeq; WP_062145025.1; NZ_KQ947984.1.
DR AlphaFoldDB; A0A124H796; -.
DR STRING; 146536.AQI70_03095; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000054024; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054024}.
FT DOMAIN 1..132
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 133..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 235
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 311
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 287
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 432 AA; 45418 MW; CB88CA2C0F44312C CRC64;
MREFIVEADG GSRGNPGPAG YGAVVIDAAT GQTLAEAAEY IGVATNNVAE YRGLLAGLRA
AHELDPTATV HVRMDSKLVI EQMSGRWKIK HPDMKPLAFE AARVFPATRV TYEWMPREQN
KHADRLANEA MDAGKRGEPW SPAASTAELA AADARAARAV AEPEPEPSGP PGDAAAGAAR
ARAALAEGRV SAAAEGRLSA AAEADVRAAR TVATPSSGWA PADMGAPATF VLLRHGETPL
TPQKRFSGSG GTDPSLSDVG REQAERVGAA LARRGTIQAV VASPLARTWE TAGIVAARLG
LEVTIDDGLR ETDFGAWEGL TFGEVRERYP EDLDAWLADP EARPTGDGES FAATATRIAA
TRDKLIAAYT GRTVLLVTHV TPIKTFVRLA LGAPPESLFR MELSAASLSA IAYYADGNAS
VRLVNDTSHL RP
//
