ID A0A124HH83_9ACTN Unreviewed; 807 AA.
AC A0A124HH83;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN ORFNames=AQI95_05795 {ECO:0000313|EMBL:KUN09329.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN09329.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN09329.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN09329.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC {ECO:0000256|ARBA:ARBA00005637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN09329.1}.
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DR EMBL; LMWN01000006; KUN09329.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A124HH83; -.
DR STRING; 67386.AQI95_05795; -.
DR OrthoDB; 9806701at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0004336; F:galactosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR049162; GH59_C.
DR InterPro; IPR049161; GH59_cat.
DR InterPro; IPR001286; Glyco_hydro_59.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR Pfam; PF02057; Glyco_hydro_59; 1.
DR Pfam; PF21708; Glyco_hydro_59_C; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR PRINTS; PR00850; GLHYDRLASE59.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..807
FT /note="galactosylceramidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007173332"
FT DOMAIN 683..807
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 807 AA; 85049 MW; 88B6CA176E96BA85 CRC64;
MREEKAVFRR TRGRRPVRRL AVAALVAVLG LFVPPPASAS TSPRTAVTTS ITVDGTKPGR
VFDGIGAISG GGGNSRLLID YPEPQRSQIL DYLFKPGYGA SLQVLKLEIG GDANSTDGSE
PSVEHSKGVV NCDAGYEFWL AEQAKVRNPN IELYGLAWTA PGWIDGGSGN FWSQDTIDYL
MTWLGCAKTH HLKIDFLGGW NERGHQAAWY ENLHATLRAK GYATKVVGDD TDWSTADTMV
TDPAFAAAVD VVGAHYPCSG GDGGDALTCP STPNALATGK PLWAGENGSQ DIHSGAAPQI
RSIVRGYLDG RITATLNWPV LAAITPNLPY PTVGLAVAPE PWSGFYRVGT ETWGTAQVTQ
FTQPGWRFID SASGYLGGAR ANGGYITLHS GADYSTIIET TTATSAQTAN VTVTGGLSTA
AVHVWSTDLS SSDPTRQFVR DADITPAGGT YSITLQPNHI YTLTTTTGQG KGTATAPAHG
PLTLPYSDDF SSYRVGSEAR YLSDMQGSYE VQPCADGRTG TCLQQMAPVK PIEWQDDSDA
FSVVGDVGWG NYTVSADVDL ARPGTVELLG RANYQSRPQA DQAGYWFRVS DTGAWSIVRS
DTTGVYTTLA HGTTASLGTG RWHHLAFTLQ GPSLSAAVDG TTVGSVQDRT WTNGQAGLGV
VGYAADQFSD LTITPGSGSS APAGPITSAL PGKCVDDNAG SAVNGTSVQM WDCSGSAAQQ
WTYTNQTLNT NGTCMDVTGH GTANGTLVEV WDCNGGNNQK WAPQPNGSLV SAESGKCLDD
PGFSTVNGTQ LEIWDCNGGA NQKWTLP
//
