ID A0A124HYR6_9ACTN Unreviewed; 327 AA.
AC A0A124HYR6; A0A124H2N3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=DNA polymerase III PolC-type {ECO:0000313|EMBL:AYC42289.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:AYC42289.1};
DE SubName: Full=DNA polymerase III subunit epsilon {ECO:0000313|EMBL:KUN68726.1};
GN Name=polC_2 {ECO:0000313|EMBL:AYC42289.1};
GN ORFNames=AQJ54_12485 {ECO:0000313|EMBL:KUN68726.1}, DWG14_06581
GN {ECO:0000313|EMBL:AYC42289.1};
OS Streptomyces griseorubiginosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN68726.1, ECO:0000313|Proteomes:UP000054375};
RN [1] {ECO:0000313|EMBL:KUN68726.1, ECO:0000313|Proteomes:UP000054375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN68726.1,
RC ECO:0000313|Proteomes:UP000054375};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT strain for the species Streptomyces griseorubiginosus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AYC42289.1, ECO:0000313|Proteomes:UP000265765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3E-1 {ECO:0000313|EMBL:AYC42289.1,
RC ECO:0000313|Proteomes:UP000265765};
RA Kang H.J., Kim S.B.;
RT "Production of Trimethoprim by Streptomyces sp. 3E-1.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP032427; AYC42289.1; -; Genomic_DNA.
DR EMBL; LMWV01000006; KUN68726.1; -; Genomic_DNA.
DR RefSeq; WP_062024267.1; NZ_KQ948735.1.
DR AlphaFoldDB; A0A124HYR6; -.
DR KEGG; sge:DWG14_06581; -.
DR OrthoDB; 190275at2; -.
DR Proteomes; UP000054375; Unassembled WGS sequence.
DR Proteomes; UP000265765; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleotidyltransferase {ECO:0000313|EMBL:AYC42289.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054375};
KW Transferase {ECO:0000313|EMBL:AYC42289.1}.
FT DOMAIN 22..186
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 243..321
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REGION 213..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36016 MW; 177AA387F0F55AC6 CRC64;
MLEDQTTAAS SPTAWPAAYP QGYAVVDVET TGLARDDRII SAAVYRLDAR GEVEDHWYTL
VNPERDPGPV WIHGLTSDTL EGAPLFQDIA EEFSARLDGR VLVAHNAVFD WQMIAREYAR
AGRVAPVSQR LCTIVLSKEL GLPLPNHKLE TLAAHFGVVQ RRAHHALDDA RVLAEAFRPS
LRAAAARSVR LPLHECRPLT EWTDRAVPRQ PSGYGSYRPT SWRPARKRPA CPYPNPGRYV
DGRPLKQGMR IAFSGDTSTE RDLLEDRAIE AGLHVATSIS RLTSLLVTND PDSGTSKVVK
ARQFGTPVVD EAAFGQLLRD VEPASEG
//
