ID A0A124I2J5_9ACTN Unreviewed; 2296 AA.
AC A0A124I2J5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KUN80820.1};
GN ORFNames=AQJ64_24885 {ECO:0000313|EMBL:KUN80820.1};
OS Streptomyces griseoruber.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN80820.1, ECO:0000313|Proteomes:UP000052982};
RN [1] {ECO:0000313|EMBL:KUN80820.1, ECO:0000313|Proteomes:UP000052982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN80820.1,
RC ECO:0000313|Proteomes:UP000052982};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseoruber DSM 40281, type strain
RT for the species Streptomyces griseoruber.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN80820.1}.
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DR EMBL; LMWW01000040; KUN80820.1; -; Genomic_DNA.
DR RefSeq; WP_059202991.1; NZ_KQ948772.1.
DR STRING; 1943.AQJ64_24885; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000052982; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 670..1106
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1686..1765
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1195..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1775..1811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2296 AA; 236612 MW; F93091EE550F55A3 CRC64;
MTSAARSEDM IIGITPFGAP DARLALAVGR AGGLGVLDLG PGDRRTREAL ARLRRASPGA
YGVRVGPGCR LTPDDLPPAG AGPHTVVLCV DAPWPVAEVA ARYRVLVEVT GLAGAAEAAR
AGAHGLIARG TECGGRVGGL GTFVLLQQLL AAQEVGLPVW ACGGIGPRTA AAAVAGGAAG
VVLDSQLALL DDSALPEPAA AALRAMDGSE TVVLAGHRVL RRRGPDAPRV PEDAGPEAVA
ALLGARDPRT ELLPVGQDGF LAARFAERWG DARRTVRALR EAVLDAVRDD TALRALRPES
PMSRALGTRL PLAQGPMTRV SDEASFAAAV AAEGALPFLA LALADGARTR ELLAATRDAV
AGRPWGVGVL GFAPEEVRAA QLEAVRELRP THAVIAGGRP SQAQALERDG IRTFLHVPSP
GLLRQFLQAG ARRFVFEGSE CGGHVGPRAG FPLWEAQLAV LEDHLAEADG SDLEVFFAGG
VHDERSAAMV AALAAPLTAR GAAVGVLMGT AYLFTEEAVA HGAIRPLFQR QVLAAEGTTL
LESAPGHATR CVPSPFAADF RTQEARLRAQ GVPERQVWEE LERLNVGRLR LASKGVTRDG
DGALTPVDER RQYAEGMFMA GEVAVLRSAT TTLAALHASV TTGAADHLSL RAAELGVTAD
GRQAPGAPAP LDIAVVGMAC MFPQAPDLPT FWANVVGGVD AVGEVPADRW DPAVHHGEST
PSKWGGFLPP IPFDPLRYGI PPASLGSVEP VQLLSLEAAR RALEDAGYGD GGREFDRSRT
SVVFGAEAGS DLSNAATLRA VLPSYYGKVP AGLEEQLPRL TEDSFPGMLA NVISGRIANR
LDLGGANYTV DAACASSLAA VDVACKELVG GTSDVVLCGG ADLHNGINDY VLFSSVHALS
PTGRSRAFDG SADGIALGEG VACVVLKRLA DAERDGDRIY GVVKGLGASS DGRSLGLTAP
RPEGQRSALE RAYRSAGVSP ADVGLVEAHG TGTVVGDRTE LRILSEVFTE AGAETGACVL
GSVKSQIGHT KCAAGLAGMI KTLLALYTGV RPPTLHVEAP NAAWDADSPF AFHAEARPWA
APAAERLAGV SAFGFGGTNF HAVLSAYADG APPVRGLDAW PAELFLFRGR DEAAAHRAVE
ELLRAAEAEG RPWRLRDLAL SAARRSDASG DPVRIAVVAT DVDDLTGKLR RALRGESDPR
HGLHPHDPQD GAVAFLFPGQ GSQRPGMLAE LFLVFPELRP YLELGRAHAD ALYPPAAFDE
SAREGQRAAL TDTRVAQPAL GVAGLAAHAV LTAAGVRPDM AAGHSYGELV ALCAAGALDP
DTLLELSAER AAAILDAASG AGPEPGTMAA VAAGAEEVAR ALRTAGAPDS VVLANRNSPE
QTVISGPTDA VTDAVRLLRE AGLGAKRIPV ACAFHSPLVA GAADRFAAAL AERPVHAPEF
PVWANRTAAP YPADPDAVRA GLAAQIGAPV AFAEQIEAMY EAGARVFVEA GPGSVLTRLV
GQILGDRPHR TVACEPRPGG GLPGWLDALA RLAVAGLPVR TGGLLRGRDA VDAVHAPAPK
RPGWTVDGQL VRTASGALLP GALAPARRVG DPVERTVPTV TTNPPHGVPA DRDALISEFL
RTSREMIAAQ RDVLLTYFGA TPGAHLPAPL APRTEGRPEA IPAVPALAAV PAPAPAPVPE
PAPAPAGDTD VQQVVLEIIS EHTGYPVDMI EPDLDLEADL SIDSIKRAEI AGELAKRLGA
GGAADLASLD DAELEELAKA RTAAAVTDWL RSRLDGPAPA GAASGPADAG PSGPPDGEPS
GPPVDEVTGE PPRRHVLRPV LLDSAASDPS AVLSGTRWAL LGDAPQAAAR LAAHGAEVVV
HARDHALSEA DGPVDGVLYL GALAGPEDDV PVLPDAFGVL KAALGRGPRR LLAVRHLDGG
APNARSAGLR GLFRTVAREY PQTLARLVDL ADASPDAVAR AVVEEAVAAD RTPVVVRAEG
GRYGFELVAE DLGALGSTGA GPAGDGVAEA AALGLEQDSV VVLTGGARGI TAQFAAALAG
AARCRLELLG RTPAPDGPED PDTAGARTTA ELRSVLAARG GLKPAEINRA AELLLAQREI
TATLGELTAL GARVRYRSVD FREPEAVVQA VKEIHAEHGR LDGVVHAAGI IEDRLIAEKT
AESFQRVYGT KATGADALLT ALEELPSTPA FTVLFGSISA VLGNRGQVDY AAANDALETL
GAAFAARTGR RAVTVHWGPW APAPGHGGMV GSELAREYAR RGIRLIDPEE GTAALLRELA
WGDPSVTAVV HTASGW
//
