ID A0A124IB03_9ACTN Unreviewed; 629 AA.
AC A0A124IB03;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Propionate--CoA ligase {ECO:0000313|EMBL:KUO07325.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:KUO07325.1};
GN Name=prpE {ECO:0000313|EMBL:KUO07325.1};
GN ORFNames=AQJ58_35195 {ECO:0000313|EMBL:KUO07325.1};
OS Streptomyces sp. DSM 15324.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1739111 {ECO:0000313|EMBL:KUO07325.1, ECO:0000313|Proteomes:UP000053431};
RN [1] {ECO:0000313|EMBL:KUO07325.1, ECO:0000313|Proteomes:UP000053431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15324 {ECO:0000313|EMBL:KUO07325.1,
RC ECO:0000313|Proteomes:UP000053431};
RA Ruckert C., Winkler A., Kalinowski J., Wink J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. DSM 15324, isolated from soil.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO07325.1}.
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DR EMBL; LMXA01000040; KUO07325.1; -; Genomic_DNA.
DR RefSeq; WP_067257746.1; NZ_KQ949037.1.
DR AlphaFoldDB; A0A124IB03; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000053431; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:KUO07325.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053431}.
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 66..445
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 510..588
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 629 AA; 67340 MW; 8B9369A736F4B42F CRC64;
MGTYEDVFRA STEDPESFWL KAAEGVDWDV APRRALDSSG APFYRWFPDG RLNVCFNALD
RHIEAGRGEQ PALVHDSPVT GTRRTYTYKQ LRDEVAAFAG ALAQLGVGHG DRVVIYMPMV
PEAAVAMLAC ARIGAVHSVV FGGFAARELA LRIDDAAPKV VVSASCGIEG KRVIAYKPLL
DEAIELAGHK PEKSVILQRP QETAALGPDD LDWADLVAAA APADCVPVAA TDPLYILYTS
GTTGKPKGVV RDSGGYAVAL HWSMGAVYDV GPGETMFTGS DVGWVVGHSY IVYAPLLVGA
TTVLYEGKPV GTPDAGQFWR VAAEYGVKTM FTAPTAFRAI RKEDPKGTLT AGYDLSHLRY
LFLAGERLDP ETYHWASDLL GVPVIDHWWQ TETGWPIVAN PVGIEAAPLK PGSPTRPLPG
WDVRVLDASG EPVPAGVDGA IVVRLPLPPG ALPTLWQDDD RYVASYLSAY DGYYLTGDSG
HLDDDGYVFV MGRTDDVINV AGHRLSTGSM EEALAAHPDV AECAVIGVAD ELKGQIPRGF
VVLKAGSDRE PGEVEAELVQ LVRERIGAVA SLKDVTVVAA LPKTRSGKIL RKTMRGIADG
HDEPIPSTVD DPGVIEALRP VLRRAGHTP
//
