ID A0A124IUR1_9CREN Unreviewed; 413 AA.
AC A0A124IUR1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Replication factor C large subunit {ECO:0000256|ARBA:ARBA00014793, ECO:0000256|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000256|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000256|ARBA:ARBA00032141, ECO:0000256|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000256|HAMAP-Rule:MF_01508};
GN ORFNames=AT710_05520 {ECO:0000313|EMBL:KUO91880.1};
OS Thermocladium sp. ECH_B.
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Thermocladium.
OX NCBI_TaxID=1714261 {ECO:0000313|EMBL:KUO91880.1, ECO:0000313|Proteomes:UP000054381};
RN [1] {ECO:0000313|EMBL:KUO91880.1, ECO:0000313|Proteomes:UP000054381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jay Z.J., Beam J.P., Kozubal M.A., Jennings R.D.E., Rusch D.B.,
RA Inskeep W.P.;
RT "The distribution, diversity and function of predominant Thermoproteales in
RT high-temperature environments of Yellowstone National Park.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000256|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000256|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000256|ARBA:ARBA00006878, ECO:0000256|HAMAP-
CC Rule:MF_01508}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO91880.1}.
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DR EMBL; LOBW01000034; KUO91880.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A124IUR1; -.
DR STRING; 1714261.AT710_05520; -.
DR Proteomes; UP000054381; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01508};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01508};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01508}.
FT DOMAIN 40..164
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 48..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01508"
SQ SEQUENCE 413 AA; 46674 MW; 54827D3936909BF7 CRC64;
MHIPWVEKYR PRSLKDVINQ EEAKAKLEEL INKWLKGERL SKGILLAGPP GVGKTTIIHA
LANDYGLEVL ELNASDVRTG DRISKIVGRS IKEASIFGFR GKLILFDEMD GLDLKEDRGS
VGEIIKIINE SRFPIVMTAN DPWDPKLRDL RERSEVIQLK PLKESDVAKL LRKICEAEKI
RCEEDAIKLL AKASMGDARA AINDLEAVAR GRSSVTEDDI AAISYRAHQV DMFRVVDMAI
KARSFDEARR VTSLPSFDWE SFFTWIVDSV PAAYGEAPTA LFDAMNNLSR ADVIRGRINR
IQEWELMKYM LELMTAGVSL VPGKPKLPFF IKYGYPAKIR LLNKIKAMRQ IRDILIKKLR
EEAHLGSRVI TLEVLPMLRL LINGERGGHV ISELSRLTGL SEDELRMALS TEI
//
