ID A0A125MGE3_BACSE Unreviewed; 659 AA.
AC A0A125MGE3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Toprim domain protein {ECO:0000313|EMBL:KWR56954.1};
GN ORFNames=AA415_00409 {ECO:0000313|EMBL:KWR56954.1};
OS Bacteroides stercoris.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=46506 {ECO:0000313|EMBL:KWR56954.1, ECO:0000313|Proteomes:UP000056419};
RN [1] {ECO:0000313|EMBL:KWR56954.1, ECO:0000313|Proteomes:UP000056419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL09T03C01 {ECO:0000313|EMBL:KWR56954.1,
RC ECO:0000313|Proteomes:UP000056419};
RX PubMed=26768901; DOI=10.1186/s12864-016-2377-z;
RA Coyne M.J., Roelofs K.G., Comstock L.E.;
RT "Type VI secretion systems of human gut Bacteroidales segregate into three
RT genetic architectures, two of which are contained on mobile genetic
RT elements.";
RL BMC Genomics 17:58-58(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWR56954.1}.
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DR EMBL; LRGC01000002; KWR56954.1; -; Genomic_DNA.
DR RefSeq; WP_060385134.1; NZ_LRGC01000002.1.
DR AlphaFoldDB; A0A125MGE3; -.
DR STRING; 46506.AA415_00409; -.
DR PATRIC; fig|46506.5.peg.443; -.
DR Proteomes; UP000056419; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd01029; TOPRIM_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR Pfam; PF01751; Toprim; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Reference proteome {ECO:0000313|Proteomes:UP000056419};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 244..336
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 373..636
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
SQ SEQUENCE 659 AA; 73450 MW; C37BE1F6FDC35106 CRC64;
MKPFYYLSDF PERRRAGKNY IAECPKCGKK HLAISRDTGL YCCFYAGCDF HGKLKDFWTE
RRNTGWQDAG SLAGASPMAK GSAGKGEPGG MASVGGGNAA FEVSMIPEDY KRLSPEVIAK
IKPLTDDPET SDTGQLAARR YLADMGISLK TAIDARIGCL VHRCFGGKDS KDGKDKKNAA
GMMYQCIAYV NYINGQPVNV KYRSCDATAS GYTKCWSQDS PTTPCPPYNI DCINPLLIAE
ENIPRLIVTE GERDVLTLRE AGYPYVISVP NGAASDLSKG FEAFRPWLDR VQELVICGDS
DLPGRTLVKH LADYFGTRCL FTVLPGGCKD ISDVLVAYGA DVVREIIGSA CPHRTSDIIT
VSERADEIMN VLNGNYDHGY DVGYGPLTDR VFHPTDQGGL IIATGKPNSG KTDFLNDLTC
RLMAKTGRNV CYLSFEVPDK NKHMANLIRL MLGKVNTAAY TREQLQPIVS FLDGHMVHLD
LHEVSPTPAN IIERAERVKR AMPLKYLIID PYLFMEMETG RYNTETQAIK GMLTQMQAWG
RNNGVWVIIV AHPRSLKKLN GKNELEEIDM YTISGSANWA NLADFIFSIS RIEEPDRRYT
RLDMLKVRDQ DLCRTGSVLF VRQPCGRYDE RESEEQIMTE MQGKVLDKDR LPWMGLVTP
//
