ID A0A125MGS6_9BACE Unreviewed; 390 AA.
AC A0A125MGS6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Efflux RND transporter periplasmic adaptor subunit {ECO:0000313|EMBL:KAA5411899.1};
GN ORFNames=F2Y81_27695 {ECO:0000313|EMBL:KAA5411899.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:KAA5411899.1, ECO:0000313|Proteomes:UP000448877};
RN [1] {ECO:0000313|EMBL:KAA5411899.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5411899.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA5411899.1}.
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DR EMBL; VVYV01000090; KAA5411899.1; -; Genomic_DNA.
DR RefSeq; WP_060407871.1; NZ_VVYV01000090.1.
DR AlphaFoldDB; A0A125MGS6; -.
DR STRING; 246787.BcellWH2_02510; -.
DR GeneID; 66306134; -.
DR eggNOG; COG0845; Bacteria.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF23; MULTIDRUG RESISTANCE PROTEIN MEXA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..390
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030020635"
FT DOMAIN 56..279
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 133..160
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 390 AA; 42520 MW; CF296514A4E7A568 CRC64;
MKSRLILLAC CLSLFSCGQS DKTTGKAPEF AVITVETTTA NLTNSYPATI RGKQDVEIRP
MVSGFITKLH VDEGSVVRKG QVLFSIDPVQ YQAAVNSAKA AVETAKAAVN TQELTVNNKR
ELNKKNIISN YDLQMAENQL AQTKAQLAQA EAQLVNAKNN LSYTSVTSPS DGVVGSIPYR
VGSLVSPSVA NPLTTVADIS EMYAYFSMTE RQLLSQIREG GSIKEILERM PDVQLQLIDG
TMYADSGRVE TISGVIDQTT GSVTMRALFP NKHNVLRSGS TGNVVFPNPM TDVIMIPQSA
TTEIQDKKFV FVLQPDNTLK NTEIKVFKLN DGKYYYVTEG LKAGDKVVME GVQNLRDGAA
ITPITPAEKE AEYQKALKDQ KEGNIQTAFN
//
