ID A0A125MHC2_9BACE Unreviewed; 770 AA.
AC A0A125MHC2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Family 65 glycosyl hydrolase {ECO:0000313|EMBL:KAA5418439.1};
GN ORFNames=F2Y81_11550 {ECO:0000313|EMBL:KAA5418439.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:KAA5418439.1, ECO:0000313|Proteomes:UP000448877};
RN [1] {ECO:0000313|EMBL:KAA5418439.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5418439.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA5418439.1}.
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DR EMBL; VVYV01000017; KAA5418439.1; -; Genomic_DNA.
DR RefSeq; WP_007217409.1; NZ_VVYV01000017.1.
DR AlphaFoldDB; A0A125MHC2; -.
DR STRING; 246787.BcellWH2_01302; -.
DR eggNOG; COG1554; Bacteria.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF14; MALTOSE PHOSPHORYLASE; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KAA5418439.1}.
FT DOMAIN 14..265
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 322..688
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 698..758
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT ACT_SITE 488
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
SQ SEQUENCE 770 AA; 89611 MW; C30C00CC3D27903C CRC64;
MKRYLKTDEW NIIEDNFHAD NLRMSESIFS LGNGRFGQRG NFEEPYSSDS YRGSFVAGIT
FLDKTRVGWW KNGFPHFYTR IPNAADWSRV SLRLIDEELD LAQWDVNSFS RRLDMKAGIS
YRDFEITSPK GHQIRVHVEH INNMAHPDLC LIKYSVTSIN YTGRISLIPS LDAIIVNKDD
DPNEKIWNIL RSGVTKDCAY LWTQTRREDA QVCYAMTYQF FKNGKEATSN PIRIEKEKQT
GFSIGADVKP GDNVMLIKYT VISSSLYDER QELIEHSIAK ARQTKIDGWD KLGNDHQQAW
TNIWKEMDVV IEGDPEAQQG IRYNIFQLCQ TYRGDDPRLN IGPKGFTGEK YGGNTYWNTE
LCCVPFFLLS TPREIVKNLL IYRYNQLPKA IENARKLGFK EGAALFPQVT YSGEECHSEW
EITFEEIHRN NIIVYAIAQH AAITGSKDYV AKYGLEVMIA VSRFWSQRVS FSKPKQKYVI
LGVTGPDEYE NNVDNNWYTN YSCVQCLRMT LNYLEIIAGE YPDEYARVRR VTNLRQQEEA
ERWRDIINHM YLPEDKELGI FVQNDGFLDK ELNSTDAIPP EERPINQHWS WDRILRSCYI
KQSDVLLGLY LYYFNFDKET VRRNFDFYET MTVHESSLSP HIHSILAARI GEVEKAYQLF
LHATRLDLDD YNNETHQGLH ITSMPGSWLA IVRGFAGMQI LEGILSFFPV IPEKWNSYSF
QINYQGRTLH MHVGKEINIS LIAGEELNIQ VYKNVYKLKL GTDLLLRIEE
//
